ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
Polymyxins Bind to the Cell Surface of Unculturable
Open access · goldAbstract read
In one paragraph
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 49 citations in OpenAlex.
- Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance.Cell reports · 2026Article
- Virulence arsenal of Acinetobacter baumannii: mechanisms driving persistence and resistance.Archives of microbiology · 2026Review
- Differential membrane lipid disruption by lipopeptide antibiotics, colistin and turnercyclamycins.Nature communications · 2026Article
- Mutations in two-component signaling systems drive experimental evolution of tigecycline and colistin resistance inAntimicrobial agents and chemotherapy · 2025Article
- Article
- Retargeting Gram-Positive-Only Adarotene-Derived Antibacterials to Broad-Spectrum Antibiotics.Antibiotics (Basel, Switzerland) · 2025Article
- Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region.International endodontic journal · 2025Article
- Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistantMaterials today. Bio · 2025Article
- Natural peptides and their synthetic congeners acting againstRSC medicinal chemistry · 2025Review
- Cholic-Acid Derived, Guanidine-Functionalized Polymers as Broad-Spectrum Antimicrobial Agents.ACS omega · 2024Article
- Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine transferase EptA.Nature communications · 2024Article
- Exploring Structure-Activity Relationships and Modes of Action of Laterocidine.ACS central science · 2024Article
- Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii.Cell reports · 2024Article
- Synergistic Activity and Mechanism of Sanguinarine with Polymyxin B against Gram-Negative Bacterial Infections.Pharmaceutics · 2024Article
- Characterizing the role of phosphatidylglycerol-phosphate phosphatases inCell surface (Amsterdam, Netherlands) · 2023Article
- Model-informed dose optimisation of polymyxin-rifampicin combination therapy against multidrug-resistant Acinetobacter baumannii.International journal of antimicrobial agents · 2023Article
- Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae.Microbiology spectrum · 2023Article
- Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa.Journal of biomedical science · 2022Article
- Synergistic Membrane Disturbance Improves the Antibacterial Performance of Polymyxin B.Polymers · 2022Article
- Polymyxins induce lipid scrambling and disrupt the homeostasis of Gram-negative bacteria membrane.Biophysical journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 4 countries.
Yan ZhuInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Jing LuInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Mei-Ling HanInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Xukai JiangInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Mohammad A K AzadInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Nitin A PatilInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Yu-Wei LinInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Jinxin ZhaoInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Yang HuInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Heidi H YuInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Ke ChenInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
John D BoyceInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Rhys A DunstanInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Trevor LithgowInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Christopher K BarlowMonash Proteomics and Metabolomics Facility Monash University Melbourne 3800 Australia.
Weifeng LiSchool of Physics and State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China.
Elena K Schneider-FutschikDepartment of Pharmacology and Therapeutics University of Melbourne Melbourne 3010 Australia.
Jiping WangInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.
Bin GongSchool of Computer Science and Technology Shandong University Jinan 250100 China.
Bjorn SommerDepartment of Computer and Information Science University of Konstanz Konstanz 78457 Germany.
Darren J CreekDrug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University Melbourne 3052 Australia.
Jing FuDepartment of Mechanical and Aerospace Engineering Monash University Melbourne 3800 Australia.
Lushan WangState Key Laboratory of Microbial Technology Shandong University Qingdao Campus Qingdao 266237 China.
Falk SchreiberDepartment of Computer and Information Science University of Konstanz Konstanz 78457 Germany.
Tony VelkovDepartment of Pharmacology and Therapeutics University of Melbourne Melbourne 3010 Australia.
Jian LiInfection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.ORCID https://orcid.org/0000-0001-7953-8230
Discovery Institute · USMonash University · AUThe University of Melbourne · AUUniversity of Konstanz · DEQingdao University · CNShandong University · CNShandong University of Technology · CN
Funding
Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’R01AI132154 · NIAID · MONASH UNIVERSITY · PI LI, JIAN, VELKOV, TONY · 2017 to 2021
$4.3MCombating Deadly Gram-negative Lung Infections: An Inhalation and Systems ApproachR01AI132681 · NIAID · PURDUE UNIVERSITY · PI LI, JIAN, ZHOU, QI · 2017 to 2020
$2.4MNIAID NIH HHS R01 AI132154NIAID NIH HHS R01 AI132681
Abstract
Multidrug-resistant
Indexed as
Acinetobacter baumanniimembrane lipidomicsmolecular dynamicspolymyxinpolymyxin‐dependent resistance
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.