ArticleAdvanced optical materials2019
Biological Photonic Crystal-Enhanced Plasmonic Mesocapsules: Approaching Single-Molecule Optofluidic-SERS Sensing.
Article in Advanced optical materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Biohybrid Nanosystem Fabricated with Marine DiatomACS biomaterials science & engineering · 2025Article
- Microfluidic synthesis of gold nanoparticle-doped microspherical photonic crystal as SERS substrate for methylene blue detection.Mikrochimica acta · 2025Article
- Synthesis, X-ray crystal structure and photophysics of butterfly shape orange and red emanating polynuclear complexes of tris(dibenzoylmethanato)Ln(III) (Ln = Sm/Eu) and exo-bidentate 4,4'-bipyridine.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- A flexible semiconductor SERS substrate by in situ growth of tightly aligned TiOMikrochimica acta · 2024Article
- Fiber-Based SERS-Fluidic Polymeric Platforms for Improved Optical Analysis of Liquids.Bioengineering (Basel, Switzerland) · 2023Article
- Limit-Defying μ-Total Analysis System: Achieving Part-Per-Quadrillion Sensitivity on a Hierarchical Optofluidic SERS Sensor.ACS omega · 2023Article
- Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.International journal of molecular sciences · 2022Article
- Photonic Nano-/Microstructured Diatom Based Biosilica in Metal Modification and Removal-A Review.Materials (Basel, Switzerland) · 2022Review
- Diatom biosilica in plasmonics: applications in sensing, diagnostics and therapeutics [Invited].Biomedical optics express · 2022Review
- Ultra-Sensitive, Rapid and On-Site Sensing Harmful Ingredients Used in Aquaculture with Magnetic Fluid SERS.Biosensors · 2022Article
- Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine.ACS photonics · 2022Review
- Preparation of Plasmonic Ag@PS CompositeFrontiers in chemistry · 2022Article
- Carboxymethylcellulose reinforced starch films and rapid detection of spoiled beverages.Frontiers in bioengineering and biotechnology · 2022Article
- Fabrication and Application of SERS-Active Cellulose Fibers Regenerated from Waste Resource.Polymers · 2021Article
- Article
- Design and simulation of diatom-based microcantilever immunobiosensor for the early detection of Karnal bunt.3 Biotech · 2020Article
- Recent Advances on Diatom-Based Biosensors.Sensors (Basel, Switzerland) · 2019Review
- Tetrahydrocannabinol Sensing in Complex Biofluid with Portable Raman Spectrometer Using Diatomaceous SERS Substrates.Biosensors · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Surface-enhanced Raman scattering (SERS) sensing in microfluidic devices, namely optofluidic-SERS, suffers an intrinsic trade-off between mass transport and hot spot density, both of which are required for ultra-sensitive detection. To overcome this compromise, photonic crystal-enhanced plasmonic mesocapsules are synthesized, utilizing diatom biosilica decorated with in-situ growth silver nanoparticles (Ag NPs). In our optofluidic-SERS testing, 100× higher enhancement factors and greater than 1,000× better detection limit were achieved compared with traditional colloidal Ag NPs, the improvement of which is attributed to unique properties of the mesocapsules. First, the porous diatom biosilica frustules serve as carrier capsules for high density Ag NPs that form high density plasmonic hot-spots. Second, the submicron-pores embedded in the frustule walls not only create a large surface-to-volume ratio allowing for effective analyte capture, but also enhance the local optical field through the photonic crystal effect. Last, the mesocapsules provide effective mixing with analytes as they are flowing inside the microfluidic channel. The reported mesocapsules achieved single molecule detection of Rhodamine 6G in microfluidic devices and were further utilized to detect 1 nM of benzene and chlorobenzene compounds in tap water with near real-time response, which successfully overcomes the constraint of traditional optofluidic sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.