ArticleBioscience of microbiota, food and health2020
Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces.
Article in Bioscience of microbiota, food and health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Study on Allometric Growth and Digestive System Development in Larvae of Largemouth Bronze Gudgeon (Animals : an open access journal from MDPI · 2026Article
- Zhaqu compound improves glucose and lipid metabolism in T2DM with MASLD by modulating gut microbiota and PPARγ.Frontiers in nutrition · 2026Article
- Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents.Food science & nutrition · 2024Article
- Metabolomics analysis reveals serum biomarkers in patients with diabetic sarcopenia.Frontiers in endocrinology · 2023Article
- Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.Molecular nutrition & food research · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
The aim of this study was to verify the effect of treatment with isoxanthohumol (IX) on the metabolomics profile of mouse feces to explore the host-intestinal bacterial interactions at the molecular level. The fecal contents of several amino acids in the high-fat diet (HFD) + 0.1% IX group (treated with IX mixed in diets for 12 weeks) were significantly lower than in the HFD group. The fecal contents of the secondary bile acid deoxycholic acid (DCA) in the HFD + 180 mg/kg IX group (orally treated with IX for 8 weeks) were significantly lower than in the HFD group; the values in the HFD group were higher than those in the normal diet (ND) group. Administration of IX changed the fecal metabolomics profile. For some metabolites, IX normalized HFD-induced fluctuations.
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