Evidence map›Paper›PMID 32774998›Full record

ReviewAmerican journal of cancer research2020

Principles and treatment strategies for the use of Chinese herbal medicine in patients at different stages of coronavirus infection.

Sheng-Teng Huang, Hsiang-Chun Lai, Yu-Chun Lin, Wei-Te Huang, Hao-Hsiu Hung, Shi-Chen Ou, Hung-Jen Lin, Mien-Chie Hung

Open access · greenAbstract readReview
In one paragraph

Review in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Unraveling the Role ofInternational journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022
    Review
  10. Article
  11. Therapeutic approaches for SARS-CoV-2 infection.Methods (San Diego, Calif.) · 2021
    Review
  12. Traditional Chinese medicine in COVID-19.Acta pharmaceutica Sinica. B · 2021
    Review
  13. Viruses · 2021
    Article
  14. Article
  15. Mapping COVID-19 with nuclear imaging: from infection to functional sequelae.American journal of nuclear medicine and molecular imaging · 2021
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sheng-Teng HuangSchool of Chinese Medicine, China Medical University Taichung, Taiwan.
Hsiang-Chun LaiDepartment of Chinese Medicine, China Medical University Hospital Taichung, Taiwan.
Yu-Chun LinDepartment of Chinese Medicine, China Medical University Hospital Taichung, Taiwan.
Wei-Te HuangDepartment of Chinese Medicine, China Medical University Hospital Taichung, Taiwan.
Hao-Hsiu HungDepartment of Chinese Medicine, China Medical University Hospital Taichung, Taiwan.
Shi-Chen OuDepartment of Chinese Medicine, China Medical University Hospital Taichung, Taiwan.
Hung-Jen LinSchool of Chinese Medicine, China Medical University Taichung, Taiwan.
Mien-Chie HungGraduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University Taichung, Taiwan.
China Medical University · TWChina Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a novel, human-infecting β-coronavirus enveloped, positive-sense single-stranded RNA viruses, similar to the severe acute respiratory syndrome (SARS) infection that emerged in November 2002. In traditional Chinese medicine (TCM), the epidemic disease concepts of "febrile epidemics" (wenyi) or "warm diseases" (wenbing) are based on geographic and cultural aspects, and Chinese herbal medicine (CHM) played an important role in the treatment of epidemic diseases. CHM was widely used to treat patients suffered with SARS almost two decades ago during outbreak of SARS, with proven safety and potential benefits. TCM has also been widely used to treat cancer patients for a long history and much of them associate with immunomodulatory activity and are used to treat coronavirus-related diseases. We propose the use of CHM treatment principles for clinical practice, based on four main stages of COVID-19 infection: early, intermediate, severe, and convalescence. We suggest corresponding decoctions that exhibit antiviral activity and anti-inflammatory effects in the early stage of infection; preventing the disease from progressing from an intermediate to severe stage of infection; restoring normal lung function and improving consciousness in the severe stage; and ameliorating pulmonary and vascular injury in the convalescent stage. We summarize the pharmaceutical mechanisms of CHM for treating coronavirus via antiviral, anti-inflammatory and immunomodulatory effects.

Indexed as

Chinese herbal medicine (CHM)Coronavirus disease 2019 (COVID-19)febrile epidemics (wenyi)severe acute respiratory syndrome (SARS)traditional Chinese medicine (TCM)warm diseases (wenbing)

Identifiers

PMID32774998
PMCPMC7407358
OpenAlexW3048895662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.