Evidence map›Paper›PMID 32774832›Full record

ArticleInternational journal of inflammation2020

The Effect of Lithium on Inflammation-Associated Genes in Lipopolysaccharide-Activated Raw 264.7 Macrophages.

Raymond T Makola, Vusi G Mbazima, Matlou P Mokgotho, Vincent S Gallicchio, Thabe M Matsebatlela

Abstract read
In one paragraph

Article in International journal of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Chemical residues in tomato plant tissue andFrontiers in plant science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raymond T MakolaDepartment of Biochemistry Microbiology and Biotechnology, School of Molecular and Life Sciences, University of Limpopo (Turfloop Campus), Sovenga 0727, South Africa.ORCID https://orcid.org/0000-0001-8394-7096
Vusi G MbazimaDepartment of Biochemistry Microbiology and Biotechnology, School of Molecular and Life Sciences, University of Limpopo (Turfloop Campus), Sovenga 0727, South Africa.ORCID https://orcid.org/0000-0001-5212-1347
Matlou P MokgothoDepartment of Biochemistry Microbiology and Biotechnology, School of Molecular and Life Sciences, University of Limpopo (Turfloop Campus), Sovenga 0727, South Africa.ORCID https://orcid.org/0000-0003-0779-562X
Vincent S GallicchioDepartment of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Thabe M MatsebatlelaDepartment of Biochemistry Microbiology and Biotechnology, School of Molecular and Life Sciences, University of Limpopo (Turfloop Campus), Sovenga 0727, South Africa.ORCID https://orcid.org/0000-0001-6506-4070

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lithium remains the preferred Food and Drug Administration- (FDA-) approved psychiatric drug for treatment of bipolar disorders since its medical establishment more than half a century ago. Recent studies revealed a promising role for lithium in the regulation of inflammation, oxidative stress, and neurodegeneration

Identifiers

PMID32774832
PMCPMC7397420

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.