ArticleAmerican journal of translational research2020
A novel model of acute closed ventral spinal cord injury and its pathological changes in rats.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Effects of CFTR-ENaC on spinal cord edema after spinal cord injury.Open medicine (Warsaw, Poland) · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
objectiveTo establish a spinal cord injury (SCI) model by ventral violence and explore its pathological changes.
methodsWe first designed and made a shape-suitable impinger. SD rats were divided into 4 groups according to force momentum calculated by weight and height: Group A (350 g*28 cm), Group B (280 g*28 cm), Group C (210 g*28 cm), and Group D (sham, 0 g*0 cm). Then the anterior border of the rat's T11 centrum was hit by the by impinger via a free-falling method. Locomotor functional (Basso, Beattie and Bresnahan scale-BBB scale), GFAP expression and pathological changes, complications, and mortality were observed.
resultsThe BBB scale scores were significantly different among all groups. Contusion, hematoma, and subarachnoid hemorrhage appeared at 1-6 h after injury in group A and B. Edema was obvious and the inflammatory cell infiltrated at the time of 6-48 h. Cicatricial contracture and porosis formed at 3-4 weeks, while group C only showed sporadic punctate hemorrhage. GFAP expression changed by time and location dynamically compared with group D. Various complications appeared in the experimental groups. Intestinal obstruction was the main cause of death. The mortality was significantly different among the groups (
conclusionThe acute ventral closing SCI model could be set up successfully by a shape-suitable impinger. The procedure was simple and repetitive. Neural function deficiency, pathological changes, and mortality were consistent with the injury controlled by coup momentum. Under the condition of this model, astrocytes went through an acute damage period and continued in the further hyperplasia stage.
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32774735PMC7407696W3049684424What OpenQuestion holds
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