Evidence map›Paper›PMID 32774690›Full record

ReviewAmerican journal of translational research2020

Differential proteomics mass spectrometry of melanosis coli.

Siqi Yuan, Ping Wang, Xin Zhou, Jinjin Xu, Shenao Lu, Yan Chen, Yingjian Zhang

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Research Advances in the Role of the Tropomyosin Family in Cancer.International journal of molecular sciences · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siqi YuanDepartment of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003, Henan, China.
Ping WangDepartment of Public Health, School of Medicine, Henan University of Science and Technology Luoyang 471003, Henan, China.
Xin ZhouDepartment of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003, Henan, China.
Jinjin XuDepartment of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003, Henan, China.
Shenao LuDepartment of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003, Henan, China.
Yan ChenDepartment of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003, Henan, China.
Yingjian ZhangDepartment of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003, Henan, China.
Henan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to reveal the biological relevancy between melanosis coli (MC) with colon cancer by analyzing the proteomics differences of tissues of melanosis coli, colon cancer, and normal ones to probe into the causes and development mechanisms of MC from the perspective of biomolecules. Fourteen differential protein spots were found in the study after using two-dimensional gel electrophoresis (2-DE) and bio-mass spectrometry (MALDI-TOF/TOF-MS). Specifically, six and eight differential protein spots in the melanosis coli tissues were detected, respectively, compared with the normal tissues and colon cancer tissues. Eight kinds of proteins, including keratin 8 (KRT8), keratin 18 (KRT18), fibrinogen beta chain isoform 2 preproprotein (FGB), catalase (CAT), 26s protease regulatory subunit 10b (PSMC6), isoform 1 of tropomyosin alpha-4 chain (TPM4), carbonic anhydrase 1 (CA1), isoform of prelammin-A/C (LMNA), were retrieved through the mass spectral database, which could be deemed as associated proteins of MC and colon cancer. The different expressions in the disease tissues indicate that these proteins may be connected with the carcinogenesis of MC as well as the malignant proliferation, development, differentiation, and diffusion of cancer cells.

Indexed as

bio-mass spectrometry (MALDI-TOF/TOF-MS)colon cancerMelanosis coli (MC)proteomicstwo-dimensional gel electrophoresis (2-DE)

Identifiers

PMID32774690
PMCPMC7407713
OpenAlexW3049208243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.