ArticleEvidence-based complementary and alternative medicine : eCAM2020
Maren Pills Improve Constipation via Regulating AQP3 and NF-
Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Gastrodin alleviates loperamide-induced slow transit constipation in mice by modulating the MAPK signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The effect of indirect moxibustion with the treatment of Ma Ren Pill on patients with acute exacerbation of chronic obstructive pulmonary disease with constipation.Frontiers in medicine · 2026Article
- Integrated untargeted metabolomics and lipidomics reveals functional- and taste-related compounds in stir-friedFrontiers in nutrition · 2026Article
- Exploring the Effects of High Protein and High Inulin Composite Shrimp Surimi Gels on Constipated Mice by Modulating Gastrointestinal Function and Gut Microbiota.Foods (Basel, Switzerland) · 2025Article
- Huangqi decoction ameliorated intestinal barrier dysfunctionWorld journal of gastrointestinal surgery · 2025Article
- Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Laxative effect of Zengye granule by modulating the SCF/c-Kit pathway and gut microbiota in constipated mice.Frontiers in veterinary science · 2025Article
- Evaluation of the therapeutic effect ofFrontiers in immunology · 2025Article
- Lacidophilin tablets alleviate constipation through regulation of intestinal microflora by promoting the colonization of Akkermansia sps.Scientific reports · 2024Article
- Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review.Frontiers in physiology · 2023Review
- Analysis of Key Genes for Slow Transit Constipation Based on RNA Sequencing.International journal of general medicine · 2022Article
- Exploring Molecular Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Effects of Maren Pills on the Intestinal Microflora and Short-Chain Fatty Acid Profile in Drug-Induced Slow Transit Constipation Model Rats.Frontiers in pharmacology · 2022Article
- Transdermal Administration of Volatile Oil fromOxidative medicine and cellular longevity · 2022Article
- The potential of Quercetin to protect against loperamide-induced constipation in rats.Food science & nutrition · 2021Article
- Novel Characterization of Constipation Phenotypes in ICR Mice Orally Administrated with Polystyrene Microplastics.International journal of molecular sciences · 2021Article
- Inhibitory Effect ofDrug design, development and therapy · 2021Article
- Action Mode of Gut Motility, Fluid and Electrolyte Transport in Chronic Constipation.Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaren pills have been used to treat constipation. Aquaporin 3 (AQP3) plays a vital role in regulating water transfer in the colon. It has been reported that the downregulation of AQP3 can regulate liquid water metabolism and intestinal permeability in irritable bowel syndrome (IBS) rats' colon via NF-
methodsThe compound diphenoxylate suspension-induced STC rats received Maren pills intragastrically for 1 consecutive week to evaluate the laxative effect of Maren pills involving the regulation of AQP3 and NF-
resultsOur results revealed that treatment with Maren pills increased the stool number, moisture content of feces, and intestinal transit rate in a dose-dependent manner. Maren pills significantly increased the AQP3, fibrosis transmembrane conductance regulator (CFTR), and protein kinase A (PKA) proteins in the colon of rats and in HT-29 cells. Mechanistically, Maren pills obviously inhibited the activation of NF-
conclusionThese results suggest that the laxative effect of Maren pills is associated with the increased expression of AQP3 by downregulating NF-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.