Evidence map›Paper›PMID 32774279›Full record

ArticleCase reports in neurology

Differential Impact of Cognitive Impairment in MCI Patients: A Case-Based Report.

Valentina Pergher, Birgitte Schoenmakers, Philippe Demaerel, Jos Tournoy, Marc M Van Hulle

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valentina PergherDepartment of Cognitive Neuropsychology, Harvard University, Cambridge, Massachusetts, USA.
Birgitte SchoenmakersAcademic Centre of General Practice, KU Leuven - University of Leuven, Leuven, Belgium.
Philippe DemaerelDepartment of Neuroradiology, KU Leuven - University Hospitals Leuven, Leuven, Belgium.
Jos TournoyDepartment of Chronic Diseases, Metabolism and Ageing, KU Leuven - University Hospitals Leuven, Leuven, Belgium.
Marc M Van HulleLaboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven - University of Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild cognitive impairment (MCI) traditionally refers to an intermediate stage between healthy individuals and early Alzheimer disease. Evidence shows grey and white matter volume changes and decrease in several executive functions, albeit the relation between cognitive performance and brain volume remains unclear. Here, we discuss 3 individual cases of MCI by investigating their MRI scans and cognitive test performance. We also recruited age-matched healthy older adults serving as gold standard for both grey and white matter volume and cognitive test outcomes. Our results show the impact of cognitive impairment on cognitive test performance and grey and white matter volumes, and the role played by cognitive and brain reserve on mitigating cognitive decline. Furthermore, we add evidence to previous studies by showing an increase in white matter volume compared to healthy controls, in all 3 patients. This pattern of increased white matter volume might help us to better understand the pathological mechanisms underlying MCI which in turn could contribute to future investigations.

Indexed as

Grey matterMild cognitive ImpairmentNeuropsychological testsReserveWhite matter

Identifiers

PMID32774279
PMCPMC7383180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.