ArticleFrontiers in systems neuroscience2020
Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation.
Article in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The efficacy of combined lateral and anterior quadratus lumborum blocks in postoperative pain management following pelvic tumor resection: a randomized controlled trial.Journal of orthopaedic surgery and research · 2025Trial
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- Study Protocol: Single-Blinded, Controlled, Clinical Trial Evaluating the Feasibility of Spinal Cord Stimulation for Improving Neuropathic Pain and Rehabilitation Outcomes in Patients With Thoracic Spinal Cord Injury.Neurosurgery practice · 2025Article
- Neurogenic Bladder in Children with Myelomeningocele.Diseases (Basel, Switzerland) · 2025Review
- Bladder Responses to Thoracolumbar Epidural Stimulation in Female Urethane-Anesthetized Rats with Graded Contusion Spinal Cord Injuries.Journal of neurotrauma · 2025Article
- Epidural Electrical Stimulation for Functional Recovery in Incomplete Spinal Cord Injury.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- User-Centered Design of Neuroprosthetics: Advancements and Limitations.CNS & neurological disorders drug targets · 2025Review
- The inhibitory effect of intraspinal microstimulation of the sacral spinal cord on nonlinear bladder reflex dynamics in cats.Frontiers in neuroscience · 2025Article
- Mapping the Iceberg of Autonomic Recovery: Mechanistic Underpinnings of Neuromodulation following Spinal Cord Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model.Scientific reports · 2024Article
- Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats.Scientific reports · 2023Article
- Effects of central-peripheral FMS on urinary retention after spinal cord injury: a pilot randomized controlled trial protocol.Frontiers in neurology · 2023Article
- Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impairments of the lower urinary tract function including urine storage and voiding are widely spread among patients with spinal cord injuries. The management of such patients includes bladder catheterization, surgical and pharmacological approaches, which reduce the morbidity from urinary tract-related complications. However, to date, there is no effective treatment of neurogenic bladder and restoration of urinary function. In the present study, we examined neuromodulation of detrusor (Detr) and external urethral sphincter by epidural electrical stimulation (EES) of lumbar and sacral regions of the spinal cord in chronic rats. To our knowledge, it is the first chronic study where detrusor and external urethral sphincter signals were recorded simultaneously to monitor their neuromodulation by site-specific spinal cord stimulation (SCS). The data obtained demonstrate that activation of detrusor muscle mainly occurs during the stimulation of the upper lumbar (L1) and lower lumbar (L5-L6) spinal segments whereas external urethral sphincter was activated predominantly by sacral stimulation. These findings can be used for the development of neurorehabilitation strategies based on spinal cord epidural stimulation for autonomic function recovery after severe spinal cord injury (SCI).
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