ArticleAdvanced functional materials2020
Nanoengineered Light-Activatable Polybubbles for On-Demand Therapeutic Delivery.
Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Self-Regulated ROS Nanoplatform Enables Sequential Antibacterial Therapy and Inflammation Resolution in Periodontitis.ACS omega · 2026Article
- Covalent Organic Frameworks and 2D Materials Hybrids: Synthesis Strategies, Properties Enhancements, and Future Directions.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Insights into the Biological Activity and Bio-Interaction Properties of Nanoscale Imine-Based 2D and 3D Covalent Organic Frameworks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Network topology diversification of porous organic salts.Chemical science · 2024Article
- Current research trends of nanomedicines.Acta pharmaceutica Sinica. B · 2023Review
- Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano-Bio-Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- In Vivo Fluorescence Molecular Imaging Using Covalent Organic Nanosheets Without Labeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Composite materials based on covalent organic frameworks for multiple advanced applications.Exploration (Beijing, China) · 2023Review
- Electrocatalytic Porphyrin/Phthalocyanine-Based Organic Frameworks: Building Blocks, Coordination Microenvironments, Structure-Performance Relationships.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- A conjugated 2D covalent organic framework as a drug delivery vehicle towards triple negative breast cancer malignancy.Nanoscale advances · 2022Article
- Emerging 2D Nanomaterials for Biomedical Applications.Materials today (Kidlington, England) · 2021Article
- Hybrid Porous Crystalline Materials from Metal Organic Frameworks and Covalent Organic Frameworks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- β-Amyloid Targeting with Two-Dimensional Covalent Organic Frameworks: Multi-Scale In-Silico Dissection of Nano-Biointerface.Chembiochem : a European journal of chemical biology · 2021Article
- Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications.Nanoscale advances · 2020Review
- Nanoengineered Light-Activatable Polybubbles for On-Demand Therapeutic Delivery.Advanced functional materials · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Vaccine coverage is severely limited in developing countries due to inefficient protection of vaccine functionality as well as lack of patient compliance to receive the additional booster doses. Thus, there is an urgent need to design a thermostable vaccine delivery platform that also enables release of the bolus after predetermined time. Here, the formation of injectable and light-activatable polybubbles for vaccine delivery is reported. In vitro studies show that polybubbles enable delayed burst release, irrespective of cargo types, namely small molecule and antigen. The extracorporeal activation of polybubbles is achieved by incorporating near-infrared (NIR)-sensitive gold nanorods (AuNRs). Interestingly, light-activatable polybubbles can be used for on-demand burst release of cargo. In vitro, ex vivo, and in vivo studies demonstrate successful activation of AuNR-loaded polybubbles. Overall, the light-activatable polybubble technology can be used for on-demand delivery of various therapeutics including small molecule drugs, immunologically relevant protein, peptide antigens, and nucleic acids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.