Evidence map›Paper›PMID 32774200›Full record

ArticleAdvanced functional materials2020

Targeting Oligosaccharides and Glycoconjugates Using Superselective Binding Scaffolds.

Stefano Tommasone, Yazmin K Tagger, Paula M Mendes

Open access · hybridAbstract read
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Optimization of Nanosubstrates toward Molecularly Surface-Functionalized Raman Spectroscopy.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stefano TommasoneSchool of Chemical Engineering University of Birmingham Edgbaston Birmingham B15 2TT UK.
Yazmin K TaggerSchool of Chemical Engineering University of Birmingham Edgbaston Birmingham B15 2TT UK.
Paula M MendesSchool of Chemical Engineering University of Birmingham Edgbaston Birmingham B15 2TT UK.ORCID https://orcid.org/0000-0001-6937-7293
University of Birmingham · GB

Funding

Medical Research Council MC_PC_15032
6 · The paper itself

Abstract

Recognition of oligosaccharides is associated with very limited specificity due to their strong solvation in water and the high degree of subtle structural variations between them. Here, oligosaccharide recognition sites are created on material surfaces with unmatched, binary on-off binding behavior, sharply discriminating a target oligosaccharide over closely related carbohydrate structures. The basis for the superselective binding behavior relies on the highly efficient generation of a pure, high order complex of the oligosaccharide target with synthetic carbohydrate receptor sites, in which the spatial arrangement of the multiple receptors in the complex is preserved upon material surface incorporation. The synthetic binding scaffolds can easily be tailored to recognize different oligosaccharides and glycoconjugates, opening up a realm of possibilities for their use in a wide field of applications, ranging from life sciences to diagnostics.

Indexed as

binding scaffoldsglycan recognitionglycoproteinsoligosaccharide recognitionsuperselective bindingsynthetic materials

Identifiers

PMID32774200
PMCPMC7405978
OpenAlexW3029701075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.