Evidence map›Paper›PMID 32774156›Full record

ReviewCancer cell international2020

Circular RNAs and esophageal cancer.

Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Honglin Yan, Manli Cui, Mingxin Zhang, Lingmin Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Cancer cell international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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  20. Emerging Roles of Circular RNAs in Thyroid Cancer.Frontiers in cell and developmental biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiaoqing Zhang *Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.
Ning Lu *Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.
Li Wang *Department of Scientific Research, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi China.
Yixuan WangDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.
Minna LiDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.
Ying ZhouShaanxi University of Traditional Chinese Medicine, Xianyang, 712046 Shaanxi China.
Honglin YanDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.
Manli CuiDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.
Mingxin ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, No. 48 Feng Hao West Road, Xi'an, 710077 Shaanxi China.ORCID 0000-0002-3945-3387
Lingmin ZhangDepartment of Anesthesiology, First Affiliated Hospital, Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061 Shaanxi China.
Xi'an Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNShaanxi University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a new kind of RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and specificity. CircRNA can specifically bind to microRNAs (miRNAs) in the form of competitive endogenous RNA, thus directly or indirectly regulating the expression of related genes. In addition to the role of sponge, circRNA also regulates parental gene expression, transcriptional translation and protein modification; and it can be used as a biomarker to develop potential diagnosis and treatment methods and evaluate prognosis. Due to changes in dietary habits and genetic factors, the morbidity and mortality of esophageal cancer (EC) in the world are still high, and are prone to early metastasis. Although the diagnosis and treatment techniques have been improved in recent years, the early diagnosis of EC is not common, and the 5-year survival rate of patients is still very low. This article reviews the function and significance of circRNA and discusses the research progress of circRNA as biomarkers in EC.

Indexed as

BiomarkerCircular RNAEsophageal cancerSponge effect

Identifiers

PMID32774156
PMCPMC7397661
OpenAlexW3047049307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.