Evidence map›Paper›PMID 32774142›Full record

ArticleMediators of inflammation2020

The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma.

Hongfei Cai, Yang Li, Da Qin, Rui Wang, Ze Tang, Tianyu Lu, Youbin Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hongfei CaiDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Yang LiDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Da QinDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Rui WangDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.ORCID https://orcid.org/0000-0003-1130-8214
Ze TangDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Tianyu LuDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Youbin CuiDepartment of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.ORCID https://orcid.org/0000-0002-7434-3888
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal cancer (EC), as a serious threat to human life and health, is one of the most common cancers around the world. Many studies have suggested that many microRNAs are involved in tumorigenesis and progression.

methodsTo search for a novel and promising predictive therapeutic target or biomarker to achieve the goal of the early diagnosis and treatment of EC, we used the EC cell lines Eca-109 and KYSE-150 and normal human esophageal epithelial cells (HEECs) to investigate the effect of ABI3BP on EC.

resultsWe found that ABI family member 3 binding protein (ABI3BP) was downregulated in EC and suppressed the proliferation, activity, migration, and invasion of EC cells. ABI3BP was downregulated by miR-183, which plays the role of an oncogene.

conclusionABI3BP and miR-183 can be considered potential biomarkers for the diagnosis of patients with EC and can be effective targets for antitumor therapy.

Indexed as

Carrier ProteinsCell Line, TumorEsophageal NeoplasmsFlow CytometryGene Expression Regulation, NeoplasticHumansMicroRNAsWound HealingABI3BP protein, humanCarrier ProteinsMicroRNAsMIRN183 microRNA, human

Identifiers

PMID32774142
PMCPMC7399787
OpenAlexW3045188767

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.