Evidence map›Paper›PMID 32774120›Full record

ReviewBiochemia medica2020

Inflammatory and angiogenic biomarkers in diabetic retinopathy.

Snježana Kaštelan, Ivana Orešković, Filip Bišćan, Helena Kaštelan, Antonela Gverović Antunica

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemia medica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.

  1. Pooled it
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  14. Inflammatory Biomarkers in Diabetic Macular Edema.Journal of clinical medicine · 2026
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Snježana KaštelanDepartment of Ophthalmology, Clinical Hospital Dubrava, Zagreb, Croatia.
Ivana OreškovićSchool of Medicine, University of Zagreb, Zagreb, Croatia.
Filip BišćanAugenzentrum Mühldorf, Überörtliche Gemeinschaftspraxis, Mühldorf am Inn, Germany.
Helena KaštelanDepartment of Ophthalmology, General Hospital Dubrovnik, Dubrovnik, Croatia.
Antonela Gverović AntunicaDepartment of Ophthalmology, General Hospital Dubrovnik, Dubrovnik, Croatia.
University of Dubrovnik · HRUniversity of Zagreb · HRPraxis für Humangenetik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and a leading cause of blindness in working-age adults in developed countries. Numerous investigations have recognised inflammation and angiogenesis as important factors in the development of this complication of diabetes. Current methods of DR treatment are predominantly used at advanced stages of the disease and could be associated with serious side effects. Therefore, new diagnostic methods are needed in order to identify the initial stages of DR as well as monitoring the effects of applied therapy. Biochemical biomarkers are molecules found in blood or other biological fluid and tissue that indicate the existence of an abnormal condition or disease. They could be a valuable tool in detecting early stages of DR, identifying patients most susceptible to retinopathy progression and monitoring treatment outcomes. Biomarkers related to DR can be measured in the blood, retina, vitreous, aqueous humour and recently in tears. As the retina represents a small part of total body mass, a circulating biomarker for DR needs to be highly specific. Local biomarkers are more reliable as indicators of the retinal pathology; however, obtaining a sample of aqueous humour, vitreous or retina is an invasive procedure with potential serious complications. As a non-invasive novel method, tear analysis offers a promising direction in further research for DR biomarker detection. The aim of this paper is to review systemic and local inflammatory and angiogenic biomarkers relevant to this sight threatening diabetic complication.

Indexed as

Aqueous HumorBiomarkersChemokinesCytokinesDiabetes ComplicationsDiabetic RetinopathyHumansInsulin-Like Growth Factor ITearsVascular Endothelial Growth Factor ABiomarkersChemokinesCytokinesInsulin-Like Growth Factor IVascular Endothelial Growth Factor Aangiogenesisbiomarkersdiabetic retinopathyinflammation

Identifiers

PMID32774120
PMCPMC7394255
OpenAlexW3046670886

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.