Evidence map›Paper›PMID 32773975›Full record

ArticleJournal of Indian Society of Periodontology

Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial.

Sanjeela Rakshith Guru, K Adithya Reddy, Ravi J Rao, Shyam Padmanabhan, Rakshith Guru, T S Srinivasa

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Study on the mechanism of curcumin in the treatment of periodontitis through network pharmacology and mole-cular docking.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2023
    Article
  12. Review
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  15. Engineering Polymeric Nanosystems against Oral Diseases.Molecules (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sanjeela Rakshith GuruDepartment of Periodontology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.
K Adithya ReddyDepartment of Periodontology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.
Ravi J RaoDepartment of Periodontology, Bangalore Institute of Dental Science, Kalaburgi, Karnataka, India.
Shyam PadmanabhanDepartment of Periodontology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.
Rakshith GuruDepartment of Prosthodontics, ESIC Dental College, Kalaburgi, Karnataka, India.
T S SrinivasaDepartment of Periodontology, ESIC Dental College, Kalaburgi, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextNanoparticles, owing to their smaller size, penetrate regions inaccessible to other delivery systems, such as periodontal pockets. Thus, the present study aimed to comparatively evaluate efficacy of 2% curcumin with nanocarrier and 1% chlorhexidine gel as a local drug delivery (LDD) in the treatment of periodontal pockets. MATERIALS AND

methodsForty-five chronic periodontitis patients with pocket depth 5-7 mm in two or more teeth were selected. Full-mouth scaling and root planing (SRP) was done for all patients followed by random allocation to the three treatment groups, namely SRP group (Group 1), 2% curcumin with nanogel (Group 2), and 1% chlorhexidine gel (Group 3). Clinical parameter assessment and microbiological analysis of subgingival plaque samples for

resultsThe results showed that when the two LDD agents were used as an adjunct to SRP in chronic periodontitis, there was an improvement in all clinical parameters. Evaluation of microbiological parameters also showed a significant reduction in Aa, Pg, and Tf levels. Comparison of 2% turmeric extract with a nanocarrier system with 1% chlorhexidine gel showed that both the agents had a comparable antibacterial effect on the three selected periodontopathic bacteria.

conclusionThe present study showed that both the LDD agents showed an effective improvement of clinical and microbiologic parameters. 2% curcumin delivered with a nanocarrier system showed results comparable to chlorhexidine gel and hence shows promising future as an LDD agent in the treatment of periodontal pockets.

Indexed as

Chlorhexidinechronic periodontitiscurcuminlocal drug deliveryPluronic F127

Identifiers

PMID32773975
PMCPMC7307465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.