Evidence map›Paper›PMID 32773946›Full record

ArticleHeterocycles2020

SYNTHESIS OF 1,3,4-OXADIAZOLES AS SELECTIVE T-TYPE CALCIUM CHANNEL INHIBITORS.

Man Zhang, Bende Zou, Medha J Gunaratna, Sahani Weerasekara, Zongbo Tong, Thi D T Nguyen, Serkan Koldas, William S Cao, Conrado Pascual, Xinmin Simon Xie and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Heterocycles, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Man ZhangDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
Bende ZouAfaSci Research Laboratories, Redwood City, CA 94063, U. S. A.
Medha J GunaratnaDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
Sahani WeerasekaraDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
Zongbo TongDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
Thi D T NguyenDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
Serkan KoldasDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
William S CaoAfaSci Research Laboratories, Redwood City, CA 94063, U. S. A.
Conrado PascualAfaSci Research Laboratories, Redwood City, CA 94063, U. S. A.
Xinmin Simon XieAfaSci Research Laboratories, Redwood City, CA 94063, U. S. A.
Duy H HuaDepartment of Chemistry, Kansas State University, 1212 Mid Campus Drive, Manhattan, KS 66506, U. S. A.
Kansas State University · USAfaSci (United States) · US

Funding

Translation of bench drug discovery into bedsite facilitated by I-Corp ProgramR44NS086343 · NINDS · AFASCI, INC. · PI XIE, XINMIN SIMON · 2014 to 2020
$4.7M
Clinical Phase I trials on an IND single molecule dual inhibitor of Cav3 channels and soluble epoxide hydrolase for treatment of neuropathic painR44NS132642 · NINDS · AFASCI, INC. · PI XIE, XINMIN SIMON · 2023 to 2025
$3.0M
Development of patented tricyclic pyrones molecules for the treatment of Alzheimer’s DiseaseR44AG043203 · NIA · AFASCI, INC. · PI XIE, XINMIN SIMON · 2017 to 2018
$2.2M
Development of a Novel Medication for Alcohol Use Disorder with an Active IND Dual Inhibitor of T-Type Calcium Channel and Soluble Epoxide HydrolaseU43AA031391 · NIAAA · AFASCI, INC. · PI XIE, XINMIN SIMON, YE, JIANG-HONG · 2023 to 2024
$983k
NIAAA NIH HHS U43 AA031391NIA NIH HHS R44 AG043203NINDS NIH HHS R44 NS086343NINDS NIH HHS R44 NS132642
6 · The paper itself

Abstract

Neuropathic pain, epilepsy, insomnia, and tremor disorder may arrive from an increase of intracellular Ca

Identifiers

PMID32773946
PMCPMC7413294
OpenAlexW2990363727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.