Evidence map›Paper›PMID 32773454›Full record

GuidelineThe American journal of gastroenterology2020

ACG Clinical Guidelines: Diagnosis and Management of Achalasia.

Michael F Vaezi, John E Pandolfino, Rena H Yadlapati, Katarina B Greer, Robert T Kavitt

Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in The American journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06588348 (Corticosteroid Effect on Achalasia Variant Esophagogastric Junction Outflow Obstruction), which is not on this map. Cited by 209 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06588348 early_phase1active not recruitingnot on this mapstarted 2022, after this paper: background citation

Corticosteroid Effect on Achalasia Variant Esophagogastric Junction Outflow Obstruction

TypeinterventionalSponsorBaylor Research InstituteRan2022 to 2026Enrolled12ConditionsEsophagogastric Junction Outflow ObstructionArmsSteroid treatment, Esophageal Manometry, Survey
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Medical management of painful achalasia: a patient-driven systematic review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024
    Pooled it
  6. Pooled it
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Observational
  18. Article
  19. Article
  20. Article

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael F VaeziDivision of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
John E PandolfinoDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Rena H YadlapatiDivision of Gastroenterology, University of California San Diego School of Medicine, San Diego, California, USA.
Katarina B GreerDivision of Gastroenterology and Liver Disease, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Robert T KavittSection of Gastroenterology, Hepatology, and Nutrition, University of Chicago Medicine, Chicago, Illinois, USA.

Funding

Role of altered response to volumetric distension in esophageal diseaseP01DK117824 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2018 to 2022
$7.3M
Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of GERDR01DK092217 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JOHN E PANDOLFINO · 2012 to 2026
$5.0M
NIDDK NIH HHS P01 DK117824NIDDK NIH HHS R01 DK092217
6 · The paper itself

Abstract

Achalasia is an esophageal motility disorder characterized by aberrant peristalsis and insufficient relaxation of the lower esophageal sphincter. Patients most commonly present with dysphagia to solids and liquids, regurgitation, and occasional chest pain with or without weight loss. High-resolution manometry has identified 3 subtypes of achalasia distinguished by pressurization and contraction patterns. Endoscopic findings of retained saliva with puckering of the gastroesophageal junction or esophagram findings of a dilated esophagus with bird beaking are important diagnostic clues. In this American College of Gastroenterology guideline, we used the Grading of Recommendations Assessment, Development and Evaluation process to provide clinical guidance on how best to diagnose and treat patients with achalasia.

Indexed as

Disease ManagementEsophageal AchalasiaEsophageal Sphincter, LowerHumansManometryPeristalsis

Identifiers

PMID32773454
PMCPMC9896940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.