ArticleJournal of Alzheimer's disease : JAD2020
Patterns of Regional Cerebral Blood Flow as a Function of Obesity in Adults.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Spontaneous intracranial artery dissection: risk factors, clinical features and imaging features.Annals of medicine · 2026Article
- Sex differences in cerebrovascular function across an aerobic exercise intervention in older adults using MRI: Results from the Brain in Motion study.Physiological reports · 2026Article
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- Topological Property Impairments of Brain Functional Network in Newly-Onset Overweight/Obese Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Aquaporin-4 inhibition alters cerebral glucose dynamics predominantly in obese animals: an MRI study.Scientific reports · 2025Article
- Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice.Brain, behavior, & immunity - health · 2025Article
- Hemoglobin-to-red blood cell distribution width ratio: a new insight into cognitive protection for obese individuals.Frontiers in medicine · 2025Article
- Multimodal Imaging-Based Cerebral Blood Flow Prediction Model Development in Simulated Microgravity.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- The interactions between energy homeostasis and neurovascular plasticity.Nature reviews. Endocrinology · 2024Review
- Brain identification of IBS patients based on GBDT and multiple imaging techniques.Physical and engineering sciences in medicine · 2024Article
- Towards a Deeper Understanding: Utilizing Machine Learning to Investigate the Association between Obesity and Cognitive Decline-A Systematic Review.Journal of clinical medicine · 2024Review
- Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope.Light, science & applications · 2024Article
- High caloric intake improves neuronal metabolism and functional hyperemia in a rat model of early AD pathology.Theranostics · 2024Article
- Examining sex differences in the association between sedentary behavior and cognitive function in bariatric surgery patients.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Article
- Dobutamine-induced alternations in cerebral blood flow of healthy adults: a 3D pseudocontinuous arterial spin labeling study.BMC medicine · 2023Article
- Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation.International journal of molecular sciences · 2023Article
- The complex relationship between obesity and neurodegenerative diseases: an updated review.Frontiers in cellular neuroscience · 2023Review
- Mechanisms Underlying Cognitive Impairment Induced by Prenatal Alcohol Exposure.Brain sciences · 2022Review
- Alzheimer's genetic risk effects on cerebral blood flow across the lifespan are proximal to gene expression.Neurobiology of aging · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile obesity has been shown to be a risk factor for Alzheimer's disease, the potential mechanisms underlying this risk may be clarified with better understanding of underlying physiology in obese persons.
objectiveTo identify patterns of cerebral perfusion abnormality in adults as a function of body mass index (BMI) defined weight categories, including overweight or obese status.
methodsA large psychiatric cohort of 35,442 brain scans across 17,721 adults (mean age 40.8±16.2 years, range 18-94 years) were imaged with SPECT during baseline and concentration scans, the latter done after each participant completed the Connors Continuous Performance Test II. ANOVA was done to identify patterns of perfusion abnormality in this cohort across BMI designations of underweight (BMI < 18.5), normal weight (BMI = 18.5 to 24.9), overweight (BMI 24.9 to 29.9), obesity (BMI≥30), and morbid obesity (BMI≥40). This analysis was done for 128 brain regions quantifying SPECT perfusion using the automated anatomical labeling (AAL) atlas.
resultsAcross adulthood, higher BMI correlated with decreased perfusion on both resting and concentration brain SPECT scans. These are seen in virtually all brain regions, including those influenced by AD pathology such as the hippocampus.
conclusionGreater BMI is associated with cerebral perfusion decreases in both resting and concentration SPECT scans across adulthood.
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