Evidence map›Paper›PMID 32773339›Full record

ArticleReproductive biomedicine online2020

Verification of a ZBTB16 variant in polycystic ovary syndrome patients.

Jie Yang, Rusong Zhao, Lei Li, Guangyu Li, Ping Yang, Jinlong Ma, Shigang Zhao, Han Zhao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biomedicine online, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jie YangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China; Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China.
Rusong ZhaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China; Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China.
Lei LiDepartment of Biological Sciences, University of Notre Dame, Notre Dame IN, USA.
Guangyu LiCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China.
Ping YangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China.
Jinlong MaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China; Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China.
Shigang ZhaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China; Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China. Electronic address: zsg0108@126.com.
Han ZhaoCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China; Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China; Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China. Electronic address: hanzh80@yahoo.com.
Shandong University · CNUniversity of Notre Dame · US

Funding

Multiethnic Fine-Mapping of Polycystic Ovary Syndrome Susceptibility LociR01HD085227 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHEN, ZIJIANG, DUNAIF, ANDREA E · 2016 to 2020
$3.2M
Functional Electrical Stimulation and Volitional Effort TrainingR21HD085527 · NICHD · KESSLER FOUNDATION, INC. · PI NOLAN, KAREN J. · 2015 to 2016
$413k
NICHD NIH HHS R01 HD085227NICHD NIH HHS R21 HD085527
6 · The paper itself

Abstract

research questionThis study investigated whether rs1784692 is a risk factor for polycystic ovary syndrome (PCOS) in Han Chinese women.

designA case-control study was conducted in Han Chinese women, involving 526 PCOS patients and 522 control participants. A TaqMan MGB probe assay was used to genotype the variant rs1784692. Dominant and additive models were employed for genotype-phenotype association analysis in the PCOS and control samples.

resultsThe minor allele C of rs1784692 is protective against PCOS (odds ratio [OR] 0.556, 95% confidence interval [CI] 0.408-0.759, P = 1.83 × 10

conclusionsThe SNP rs1784692 in gene ZBTB16 is protective against PCOS but is associated with increased BMI in Han Chinese women with PCOS.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAllelesAsian PeopleCase-Control StudiesChinaFemaleGene FrequencyGenetic Association StudiesGenotypeHumansPolycystic Ovary SyndromePromyelocytic Leukemia Zinc Finger ProteinPromyelocytic Leukemia Zinc Finger ProteinPolycystic ovary syndromeSingle nucleotide polymorphismZBTB16

Identifiers

PMID32773339
PMCPMC10730780
OpenAlexW3026250856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.