Evidence map›Paper›PMID 32773237›Full record

ArticlePatient education and counseling2021

Effects of health literacy skills, educational attainment, and level of melanoma risk on responses to personalized genomic testing.

Kimberly A Kaphingst, Erva Khan, Kirsten Meyer White, Andrew Sussman, Dolores Guest, Elizabeth Schofield, Yvonne T Dailey, Erika Robers, Matthew R Schwartz, Yuelin Li and 4 more

Open access · greenAbstract read
In one paragraph

Article in Patient education and counseling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  13. Effect of Superstitious Beliefs and Risk Intuitions on Genetic Test Decisions.Medical decision making : an international journal of the Society for Medical Decision Making · 2022
    Article
  14. Article
  15. Interest and Utility ofJournal of skin cancer · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Kimberly A KaphingstHuntsman Cancer Institute and Department of Communication, University of Utah, Salt Lake City, UT, USA. Electronic address: kim.kaphingst@hci.utah.edu.
Erva KhanMemorial Sloan Kettering Cancer Center, New York, USA.
Kirsten Meyer WhiteDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Andrew SussmanDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Dolores GuestDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Elizabeth SchofieldMemorial Sloan Kettering Cancer Center, New York, USA.
Yvonne T DaileyDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Erika RobersDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Matthew R SchwartzDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Yuelin LiMemorial Sloan Kettering Cancer Center, New York, USA.
David BullerKlein Buendel, Inc., Golden, CO, USA.
Keith HunleyDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Marianne BerwickDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Jennifer L HayMemorial Sloan Kettering Cancer Center, New York, USA.
University of New Mexico · USMemorial Sloan Kettering Cancer Center · USHuntsman Cancer Institute · USKlein Buendel (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Psychosocial Palliative & Community Research in CancerT32CA009461 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JENNIFER L HAY, Jamie S. Ostroff · 1985 to 2026
$10.1M
Personalized Genomic Testing for Melanoma: Maximizing Personal Utility and ReachR01CA181241 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BERWICK, MARIANNE, HAY, JENNIFER L · 2014 to 2016
$2.1M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA181241NCI NIH HHS T32 CA009461
6 · The paper itself

Abstract

objectiveFew studies have examined how health literacy impacts responses to genetic information.

methodsWe examined this issue among 145 English or Spanish-speaking adult primary care patients enrolled in a trial that offered testing for MC1R gene variants that confer moderately increased melanoma risk. We investigated whether health literacy skills, educational attainment, or melanoma risk were related to short-term cognitive and affective responses to genetic test results.

resultsOn average, participants found the test results to be highly believable and clear, with low levels of negative emotional responses and moderate levels of positive responses. In adjusted models, health literacy skills were significantly inversely associated with confusion (OR = 0.75, 95 % CI = 0.58, 0.96); those with higher education thought significantly less about their test results (β = -0.66), were less hopeful (β = -0.89), and had lower distress (β = -1.15). We also observed a significant interaction (p < .001) between health literacy and melanoma risk in affecting the frequency of thoughts about test results.

conclusionThe findings indicate that health literacy skills may affect to what extent individuals elaborate cognitively on genetic information. PRACTICE IMPLICATIONS: Patients with lower health literacy skills or education may need support in understanding genetic test results.

Indexed as

Health LiteracyMelanomaAdultComprehensionEducational StatusGenetic TestingHumansCommunicationGenetic testingHealth literacyMelanomaReturn of results

Identifiers

PMID32773237
PMCPMC7749822
OpenAlexW3046274373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.