Evidence map›Paper›PMID 32773105›Full record

ReviewAdvances in biological regulation2020

Cancer therapy and treatments during COVID-19 era.

Shaw M Akula, Stephen L Abrams, Linda S Steelman, Saverio Candido, Massimo Libra, Kvin Lerpiriyapong, Lucio Cocco, Giulia Ramazzotti, Stefano Ratti, Matilde Y Follo and 8 more

Open access · greenAbstract readReview
In one paragraph

Review in Advances in biological regulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  9. Neglected malignant neoplasms with cutaneous involvement.Postepy dermatologii i alergologii · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Shaw M AkulaDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
Stephen L AbramsDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
Linda S SteelmanDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
Saverio CandidoDepartment of Biomedical and Biotechnological Sciences-Oncological, Clinical and General Pathology Section, University of Catania, Catania, Italy; Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy.
Massimo LibraDepartment of Biomedical and Biotechnological Sciences-Oncological, Clinical and General Pathology Section, University of Catania, Catania, Italy; Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy.
Kvin LerpiriyapongCenter of Comparative Medicine and Pathology, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medicine and the Hospital for Special Surgery, New York City, NY, USA.
Lucio CoccoDipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Giulia RamazzottiDipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Stefano RattiDipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Matilde Y FolloDipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Alberto M MartelliDipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
William L BlalockIstituto di Genetica Molecolare-Luigi Luca Cavalli Sforza, UOS Bologna, Consiglio Nazionale Delle Ricerche (IGM-CNR), Bologna, Italy; IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.
Manuela PiazziIstituto di Genetica Molecolare-Luigi Luca Cavalli Sforza, UOS Bologna, Consiglio Nazionale Delle Ricerche (IGM-CNR), Bologna, Italy; IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.
Giuseppe MontaltoDepartment of Health Promotion, Maternal and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy.
Melchiorre CervelloInstitute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy.
Monica NotarbartoloDepartment of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy.
Jorg BaseckeSankt-Josefs Hospital, Krankenhausstrasse 13, 49661, Cloppenburg, Germany.
James A McCubreyDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA. Electronic address: mccubreyj@ecu.edu.
University of Bologna · ITEast Carolina University · USInstitute for Biomedical Research and Innovation · ITIstituto Ortopedico Rizzoli · ITUniversity of Catania · ITHospital for Special Surgery · USSt. Josefs-Hospital Cloppenburg · DEUniversity of Palermo · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even routine check-ups and we are adapting to a virtual world. In many cases, surgeries are delayed unless they are essential. This is also true with regards to cancer treatments and screening. Interestingly, some existing drugs and nutraceuticals have been screened for their effects on COVID-19. Certain FDA approved drugs, vitamin, natural products and trace minerals may be repurposed to treat or improve the prevention of COVID-19 infections and disease progression. This review article will summarize how the treatments of various cancer patients has changed during the COVID-19 era as well as discuss the promise of some existing drugs and other agents to be repurposed to treat this disease.

Indexed as

PandemicsAngiotensin-Converting Enzyme 2Antineoplastic AgentsAntiviral AgentsBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19Drug RepositioningGene Expression RegulationHost-Pathogen InteractionsHumansHydroxychloroquineNeoplasmsPeptidyl-Dipeptidase APneumonia, ViralACE2 protein, humanAngiotensin-Converting Enzyme 2Antineoplastic AgentsAntiviral AgentsHydroxychloroquinePeptidyl-Dipeptidase ASpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Trace ElementsVitaminsCancerCOVID-19Natural productsNutraceuticalsRepurposing approved drugs

Identifiers

PMID32773105
PMCPMC7319627
OpenAlexW3037475073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.