Evidence map›Paper›PMID 32773089›Full record

ArticleBioorganic & medicinal chemistry2020

Labeling a TCO-functionalized single domain antibody fragment with

Zhengyuan Zhou, Michael R Zalutsky, Ganesan Vaidyanathan

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Radiosynthesis and preclinical evaluations of [American journal of nuclear medicine and molecular imaging · 2024
    Article
  6. Development ofChemical communications (Cambridge, England) · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Site-Specific and Residualizing Linker forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhengyuan ZhouDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: ganesan.v@duke.edu.
Duke Medical Center · USDuke University Hospital · US

Funding

RADIOTHERAPY USING MONOCLONAL ANTIBODIES AND ASTATINER01CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1985 to 2020
$4.6M
ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIESR37CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1999 to 2008
$3.8M
Labeling nanobodies with 18F residualizing labels for HER2 specific PET imagingR01CA188177 · NCI · DUKE UNIVERSITY · PI VAIDYANATHAN, GANESAN · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA042324NCI NIH HHS R01 CA188177NCI NIH HHS R37 CA042324
6 · The paper itself

Abstract

Single domain antibody fragments (sdAbs) exhibit a rapid tumor uptake and fast blood clearance amenable for labeling with

Indexed as

AnimalsCell Line, TumorCycloaddition ReactionCyclooctanesErb-b2 Receptor Tyrosine KinasesFemaleFluorine RadioisotopesHumansIodine RadioisotopesMiceMice, NudeOvarian NeoplasmsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsSingle-Domain AntibodiesTissue DistributionCyclooctanesErb-b2 Receptor Tyrosine KinasesFluorine-18Fluorine RadioisotopesIodine-125Iodine RadioisotopesRadiopharmaceuticalsSingle-Domain AntibodiesFluorine-18HER2Inverse electron-demand Diels-Alder reactionPET imagingRenal brush border enzyme-cleavable linkerSingle domain antibody fragment (VHH, Nanobody)

Identifiers

PMID32773089
PMCPMC7458057
OpenAlexW3041165680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.