ArticleJournal of neurotrauma2021
Multi-Scale White Matter Tract Embedded Brain Finite Element Model Predicts the Location of Traumatic Diffuse Axonal Injury.
Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion.Neurobiology of disease · 2026Review
- Mechanical deformation explains distinct neuroimaging patterns and etiologies in brain trauma.NeuroImage · 2026Article
- Effect of modeling subject-specific cortical folds on brain injury risk prediction under blunt impact loading.Biomechanics and modeling in mechanobiology · 2026Article
- Mechanisms of inflammatory response in secondary brain injury: a review of computational approaches, challenges, and future directions.Biomechanics and modeling in mechanobiology · 2026Review
- In Vivo Brain Deformation in a Sheep Model of Rapid Head Rotation.Annals of biomedical engineering · 2026Article
- Simultaneous Reactive Change in Unmyelinated and Myelinated Axon Segments Following Experimental Diffuse Traumatic Brain Injury.Journal of neurotrauma · 2026Article
- Noninvasive mapping of shear strain predicts the anatomical distribution of mild traumatic brain injury.NeuroImage. Clinical · 2026Article
- MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.Acta neuropathologica communications · 2025Article
- Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury.Annals of biomedical engineering · 2025Article
- Average Biomechanical Responses of the Human Brain Grouped by Age and Sex.Annals of biomedical engineering · 2025Article
- Exploring Sex-Based Variations in Head Kinematics During Soccer Heading.Annals of biomedical engineering · 2025Article
- Quantitative video analysis of head acceleration events: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Cellular mechanisms of traumatic brain injury.npj biological physics and mechanics · 2025Review
- Adaptive Machine Learning Head Model Across Different Head Impact Types Using Unsupervised Domain Adaptation and Generative Adversarial Networks.IEEE sensors journal · 2024Article
- Position-based assessment of head impact frequency, severity, type, and location in high school American football.Frontiers in bioengineering and biotechnology · 2024Article
- Machine-learning-based head impact subtyping based on the spectral densities of the measurable head kinematics.Journal of sport and health science · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- Finding the Spatial Co-Variation of Brain Deformation With Principal Component Analysis.IEEE transactions on bio-medical engineering · 2022Article
- A biomechanical-based approach to scale blast-induced molecular changes in the brain.Scientific reports · 2022Article
- Oblique impact responses of Hybrid III and a new headform with more biofidelic coefficient of friction and moments of inertia.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Finite element models (FEMs) are used increasingly in the traumatic brain injury (TBI) field to provide an estimation of tissue responses and predict the probability of sustaining TBI after a biomechanical event. However, FEM studies have mainly focused on predicting the absence/presence of TBI rather than estimating the location of injury. In this study, we created a multi-scale FEM of the pig brain with embedded axonal tracts to estimate the sites of acute (≤6 h) traumatic axonal injury (TAI) after rapid head rotation. We examined three finite element (FE)-derived metrics related to the axonal bundle deformation and three FE-derived metrics based on brain tissue deformation for prediction of acute TAI location. Rapid head rotations were performed in pigs, and TAI neuropathological maps were generated and colocalized to the FEM. The distributions of the FEM-derived brain/axonal deformations spatially correlate with the locations of acute TAI. For each of the six metric candidates, we examined a matrix of different injury thresholds (th
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.