Evidence map›Paper›PMID 32772807›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Multiple sclerosis management during the COVID-19 pandemic.

Brandon P Moss, Kedar R Mahajan, Robert A Bermel, Kelsey Hellisz, Le H Hua, Timothy Hudec, Scott Husak, Marisa P McGinley, Daniel Ontaneda, Zhini Wang and 16 more

Abstract read
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Systematic review of risk of SARS-CoV-2 infection and severity of COVID-19 with therapies approved to treat multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  3. The prevalence of COVID-19 infection in patients with multiple sclerosis (MS): a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Impact of COVID-19 and system recovery in delivering healthcare to people with multiple sclerosis: a population-based Study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  13. Review
  14. Article
  15. The influence of the COVID-19 pandemic on the prescription of multiple sclerosis medication in Germany.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Multiple Sclerosis Management During the COVID-19 Pandemic.Current neurology and neuroscience reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Brandon P MossMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-5319-5129
Kedar R MahajanMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-0339-9876
Robert A BermelMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Kelsey HelliszMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Le H HuaLou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA.ORCID 0000-0002-0535-3978
Timothy HudecMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Scott HusakMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Marisa P McGinleyMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Daniel OntanedaMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-2838-9148
Zhini WangDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Malory WeberMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
Paula TaglianiServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.
Simón Cárdenas-RobledoServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ana ZabalzaServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0003-3860-5251
Georgina ArrambideServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-2657-5510
Pere Carbonell-MirabentServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.
Marta Rodríguez-BarrancoServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.
Jaume Sastre-GarrigaServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-1589-2254
Mar TintoreServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0001-9999-5359
Xavier MontalbanServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (CEMCAT), Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Universitat Autònoma de Barcelona, Barcelona, Spain.
Morgan DouglasDivision of Neuroimmunology and Neurological Infections, Johns Hopkins University, Baltimore, MA, USA.
Esther OgbuokiriDivision of Neuroimmunology and Neurological Infections, Johns Hopkins University, Baltimore, MA, USA.
Berna AravidisDivision of Neuroimmunology and Neurological Infections, Johns Hopkins University, Baltimore, MA, USA.
Jeffrey A CohenMellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-9245-9772
Ellen M MowryDivision of Neuroimmunology and Neurological Infections, Johns Hopkins University, Baltimore, MA, USA.
Kathryn C FitzgeraldDivision of Neuroimmunology and Neurological Infections, Johns Hopkins University, Baltimore, MA, USA.

Funding

Institutional Career Development CoreKL2TR002547 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI DWEIK, RAED A. · 2018 to 2022
$7.7M
Thalamic MRI, histopathologic, and clinical correlations in multiple sclerosisK23NS109328 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI MAHAJAN, KEDAR · 2018 to 2022
$919k
Circadian Rhythms and Sleep, Structural Neuroimaging and Depression in People with Multiple SclerosisK01MH121582 · NIMH · JOHNS HOPKINS UNIVERSITY · PI FITZGERALD, KATHRYN C. · 2019 to 2022
$675k
NCATS NIH HHS KL2 TR002547NIMH NIH HHS K01 MH121582NINDS NIH HHS K23 NS109328
6 · The paper itself

Abstract

backgroundPeople with multiple sclerosis (MS) may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs) and greater need for medical services.

objectivesTo evaluate risk factors for COVID-19 susceptibility and describe the pandemic's impact on healthcare delivery.

methodsSurveys sent to MS patients at Cleveland Clinic, Johns Hopkins, and Vall d'Hebron-Centre d'Esclerosi Múltiple de Catalunya in April and May 2020 collected information about comorbidities, DMTs, exposures, COVID-19 testing/outcomes, health behaviors, and disruptions to MS care.

resultsThere were 3028/10,816 responders. Suspected or confirmed COVID-19 cases were more likely to have a known COVID-19 contact (odds ratio (OR): 4.38; 95% confidence interval (CI): 1.04, 18.54). In multivariable-adjusted models, people who were younger, had to work on site, had a lower education level, and resided in socioeconomically disadvantaged areas were less likely to follow social distancing guidelines. 4.4% reported changes to therapy plans, primarily delays in infusions, and 15.5% a disruption to rehabilitative services.

conclusionYounger people with lower socioeconomic status required to work on site may be at higher exposure risk and are potential targets for educational intervention and work restrictions to limit exposure. Providers should be mindful of potential infusion delays and MS care disruption.

Indexed as

EmploymentOccupational TherapyPhysical Therapy ModalitiesSocial ClassAdultAge FactorsBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19Delivery of Health CareDisease ManagementDisease SusceptibilityEducational StatusFemaleHealth BehaviorImmunologic FactorsCOVID-19disease modifying therapieshealth behaviorshealthcare deliverymultiple sclerosisSARS-CoV-2

Identifiers

PMID32772807
PMCPMC7424611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.