SynthesisJournal of the American Heart Association2020
Infective Endocarditis After Surgical and Transcatheter Aortic Valve Replacement: A State of the Art Review.
Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Infective Endocarditis After Surgical and Transcatheter Aortic Valve Replacement: A State of the Art Review.Journal of the American Heart Association · 2020Pooled it
- Transcatheter aortic valve-in-valve implantation for residual prosthetic valve dysfunction and paravalvular leak after healed Enterococcus faecalis prosthetic valve endocarditis: a case report.European heart journal. Case reports · 2026Article
- Infective Endocarditis of Transcatheter Aortic Valve Replacement and Transcatheter Edge-to-Edge Repair Devices.JACC. Advances · 2026Review
- Current Advances in Epidemiology, Diagnosis, and Management of TAVR-Associated Infective Endocarditis: A Narrative Review.Reviews in cardiovascular medicine · 2026Review
- Interhospital variability in 180-day infections following cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2025Article
- Fatal Complications inJournal of fungi (Basel, Switzerland) · 2025Article
- Non-pulmonary postoperative complications of cardiothoracic surgery.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Review
- Infective Endocarditis After TAVR-Surgical Challenges and Outcomes.Journal of clinical medicine · 2025Article
- ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025Article
- Article
- The Evolving Risk of Infective Endocarditis After Transcatheter Aortic Valve Implantation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Article
- Review
- Early and Very Early Post-Transcatheter Aortic Valve Implantation Infective Endocarditis: Imaging Challenges.Reviews in cardiovascular medicine · 2025Review
- Incidence and Early Mortality of Prosthetic Valve Endocarditis in Patients Undergoing TAVI Compared to SAVR: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Surgical management is associated with improved survival for endocarditis after transcatheter aortic valve replacement.Annals of cardiothoracic surgery · 2025Article
- Aortic Valve Replacement in the Current Era.Journal of clinical medicine · 2025Review
- Infective endocarditis following transcatheter mitral valve-in-valve replacement: a clinical case report.BMC cardiovascular disorders · 2025Article
- Risk factors for endogenous endophthalmitis in infectious endocarditis patients.Eye (London, England) · 2025Article
- The emerging challenge ofClinical microbiology reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosthetic valve endocarditis (PVE) after surgical aortic valve replacement and transcatheter aortic valve replacement (TAVR) carries significant morbidity/mortality. Our review aims to compare incidence, predisposing factors, microbiology, diagnosis, management, and outcomes of PVE in surgical aortic valve replacement/TAVR patients. We searched PubMed and Embase to identify published studies from January 1, 2015 to March 13, 2020. Key words were indexed for original reports, clinical studies, and reviews. Reports were evaluated by 2 authors against a priori inclusion/exclusion criteria. Studies were included if they reported incidence and outcomes related to surgical aortic valve replacement/TAVR PVE and excluded if they were published pre-2015 or included a small population. We followed the Cochrane methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for all stages of the design and implementation. Study quality was based on the Newcastle-Ottawa Scale. Thirty-three studies with 311 to 41 025 patients contained relevant information. The majority found no significant difference in incidence of surgical aortic valve replacement/TAVR PVE (reported as 0.3%-1.2% per patient-year versus 0.6%-3.4%), but there were key differences in pathogenesis. TAVR has a specific set of infection risks related to entry site, procedure, and device, including nonstandardized protocols for infection control, valve crimping injury, paravalvular leak, neo-leaflet stress, intact/calcified native leaflets, and intracardiac hardware. With the expansion of TAVR to lower risk and younger patients, a better understanding of pathogenesis, patient presentation, and guideline-directed treatment is paramount. When operative intervention is necessary, mortality remains high at 20% to 30%. Unique TAVR infection risks present opportunities for PVE prevention, therefore, further investigation is imperative.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.