ArticleThe New phytologist2021
Targeted plant hologenome editing for plant trait enhancement.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Directed Evolution of Plant-Associated Bacteria Enhances Plant Holobiont Stress Tolerance.Plant, cell & environment · 2026Article
- Transplanting drought-Protective Bacteria to enhance clove basil's (Ocimum gratissimum) drought tolerance.Scientific reports · 2025Article
- Enhancing Abiotic Stress Resilience in Mediterranean Woody Perennial Fruit Crops: Genetic, Epigenetic, and Microbial Molecular Perspectives in the Face of Climate Change.International journal of molecular sciences · 2025Review
- Deletion of ACC Deaminase in Symbionts Converts the Host Plant From Water Waster to Water Saver.Plant, cell & environment · 2025Article
- The ancestral environment of teosinte populations shapes their root microbiome.Environmental microbiome · 2024Article
- Protective role of native root-associated bacterial consortium against root-knot nematode infection in susceptible plants.Nature communications · 2024Article
- Microbe-induced phenotypic variation leads to overyielding in clonal plant populations.Nature ecology & evolution · 2024Article
- Endophytic bacterial community diversity in genetically related hybrid rice seeds.Applied microbiology and biotechnology · 2023Article
- Nodulation number tempers the relative importance of stochastic processes in the assembly of soybean root-associated communities.ISME communications · 2023Article
- Metapangenomics of wild and cultivated banana microbiome reveals a plethora of host-associated protective functions.Environmental microbiome · 2023Article
- Evidence for host-microbiome co-evolution in apple.The New phytologist · 2022Article
- Exploitation of Plant Growth Promoting Bacteria for Sustainable Agriculture: Hierarchical Approach to Link Laboratory and Field Experiments.Microorganisms · 2022Article
- Advancement in the molecular perspective of plant-endophytic interaction to mitigate drought stress in plants.Frontiers in microbiology · 2022Review
- Plant Holobiont Theory: The Phytomicrobiome Plays a Central Role in Evolution and Success.Microorganisms · 2021Review
- Microbial interventions are an easier alternative to engineer higher organisms.Microbial biotechnology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breeding better crops is a cornerstone of global food security. While efforts in plant genetic improvement show promise, it is increasingly becoming apparent that the plant phenotype should be treated as a function of the holobiont, in which plant and microbial traits are deeply intertwined. Using a minimal holobiont model, we track ethylene production and plant nutritional value in response to alterations in plant ethylene synthesis (KO mutation in ETO1), which induces 1-aminocyclopropane-1-carboxylic acid (ACC) synthase 5 (ACS5), or microbial degradation of ACC (KO mutation in microbial acdS), preventing the breakdown of the plant ACC pool, the product of ACS5. We demonstrate that similar plant phenotypes can be generated by either specific mutations of plant-associated microbes or alterations in the plant genome. Specifically, we could equally increase plant nutritional value by either altering the plant ethylene synthesis gene ETO1, or the microbial gene acdS. Both mutations yielded a similar plant phenotype with increased ethylene production and higher shoot micronutrient concentrations. Restoring bacterial AcdS enzyme activity also rescued the plant wild-t8yp phenotype in an eto1 background. Plant and bacterial genes build an integrated plant-microbe regulatory network amenable to genetic improvement from both the plant and microbial sides.
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