Evidence map›Paper›PMID 32772324›Full record

Observational studyJournal of endocrinological investigation2021

Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19.

G E Carpagnano, V Di Lecce, V N Quaranta, A Zito, E Buonamico, E Capozza, A Palumbo, G Di Gioia, V N Valerio, O Resta

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 16 pooled it
40.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 16 syntheses or guidelines pooled it, 308 citations in OpenAlex.

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  14. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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  19. Effect of Oral Vitamin D3 Supplementation in Exclusively Breastfed Newborns: Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

G E Carpagnano *Institute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
V Di Lecce *Institute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
V N QuarantaPneumology Department, "Di Venere" Hospital Bari, Bari, Italy.
A ZitoCardiology Department, "SS Annunziata" Hospital, Taranto, Italy.
E BuonamicoInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy. enricobuonamico@gmail.com.ORCID http://orcid.org/0000-0001-6348-1356
E CapozzaInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
A PalumboInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
G Di GioiaInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
V N ValerioInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
O RestaInstitute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy.
University of Bari Aldo Moro · ITOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis.

methodsIn this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020.

resultsEighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019).

conclusionsHigh prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.

Indexed as

Acute DiseaseAgedComorbidityCOVID-19Cytokine Release SyndromeFemaleHospitalizationHumansMaleMiddle AgedPrognosisRespiratory InsufficiencyRetrospective StudiesRisk FactorsSARS-CoV-2Severity of Illness IndexVitamin DAcute respiratory failureCOVID-19Mortality riskVitamin D deficiency

Identifiers

PMID32772324
PMCPMC7415009
OpenAlexW3048197845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.