SynthesisAging clinical and experimental research2021
Incidence and associated factors of delirium after orthopedic surgery in elderly patients: a systematic review and meta-analysis.
Synthesis in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early supported discharge for older adults admitted to hospital after orthopaedic surgery: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Risk factors for postoperative delirium in geriatric patients with hip fracture: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Effect of pre-infusion of hypertonic saline on postoperative delirium in geriatric patients undergoing shoulder arthroscopy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- Article
- Long-Term Cognitive and Functional Outcomes Following Postoperative Delirium and Liberal Fluid Fasting in Elderly Trauma Patients: A Prospective Single-Centre Study.Journal of clinical medicine · 2026Article
- Blood-Brain Barrier Permeability in Cases of Post-operative Delirium Is Associated with Central Nervous System Phosphatidylcholine Imbalances.Molecular neurobiology · 2026Article
- Multi-output LSTM-based prediction of postoperative delirium: integrating baseline and perioperative data for enhanced risk stratification in older spine surgery patients.BioData mining · 2026Article
- Association of Serum Sodium Levels and Delirium in Patients with Sepsis: A Retrospective Study.Biomedicines · 2026Article
- Relevance and Feasibility of a "Geriatric Delirium Pass" for Older Patients with Elective Surgeries: Findings from a Multi-Methods Study.Geriatrics (Basel, Switzerland) · 2026Article
- Identification of Risk Factors and Development of a Prediction Model for Recovery Room Delirium Following Transurethral Resection of the Prostate.Clinical interventions in aging · 2026Article
- Postoperative delirium in patients with cancer: a narrative review of major risk factors.Sao Paulo medical journal = Revista paulista de medicina · 2026Review
- Association between intraoperative blood transfusion and postoperative delirium in elderly patients undergoing total hip arthroplasty with combined spinal-epidural anesthesia: an IPTW-adjusted retrospective cohort study.BMC anesthesiology · 2025Article
- Postoperative delirium in orthopedic patients - identifying contributing factors and therapeutic strategies: A review.Medicine · 2025Review
- Reduced perioperative sensory impairment could lower postoperative delirium incidence: a before-and-after study in older patients with hip fracture.BMC geriatrics · 2025Article
- Association Between Postoperative Delirium and Loss of Melatonin Rhythm After Hip Arthroplasty: A Pilot Study.Cureus · 2025Article
- Observational
- Postoperative Delirium and Cognitive Dysfunction After Cardiac Surgery: The Role of Inflammation and Clinical Risk Factors.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Development of a LASSO machine learning algorithm-based model for postoperative delirium prediction in hepatectomy patients.BMC surgery · 2025Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA total of 4.5-41.2% of orthopedic surgery patients experience delirium. Until now, no formal systematic review or meta-analysis was performed to summarize the risk factors of delirium after orthopedic surgery.
aimsThe present study aimed to comprehensively and quantitatively conclude the risk factors of delirium after orthopedic surgery in elderly patients.
methodsA search was applied to Medline, Chinese National Knowledge Infrastructure (CNKI), Embase, and Cochrane central database (all up to February 2020). All studies on the risk factors of delirium after orthopedic surgery in elderly patients without language restriction were reviewed, and qualities of included studies were assessed using the Newcastle-Ottawa Scale. Data were pooled and a meta-analysis was completed.
resultsA total of 15 studies altogether included 10,053 patients with orthopedic surgery, 825 cases of delirium occurred after surgery, suggesting the accumulated incidence of 8.2%. Results of meta-analyses showed that age > 70 years (odds ratio (OR) 3.78, 95% confidence interval (CI) 2.97-4.80), advanced age (standardized mean difference 0.82, 95% CI 0.54-1.09), male sex (OR 1.78, 95% CI 1.13-2.79), medical comorbidities (OR 2.18, 95% CI 1.23-3.88), malnutrition (OR 3.10, 95% CI 2.19-4.38), preoperative and postoperative haemoglobin (SMD - 0.37, 95% CI - 0.54 to - 0.19; SMD - 0.33, 95% CI - 0.55 to - 0.11), postoperative sodium (SMD - 0.52, 95% CI - 0.74 to - 0.29) and longer hospitalization after surgery (SMD 0.27, 95% CI 0.11-0.43), hearing impairment (OR 2.78, 95% CI 1.98-3.90), multiple medications (OR 1.36, 95% CI 1.21-1.52), psychotic drugs(OR 4.27, 95% CI 1.37-13.24), morphine (OR 1.97, 95% CI 1.11-3.51), cognitive impairment (OR 2.72, 95% CI 1.96-3.78), length of stay (SMD 0.26, 95% CI 0.14-0.39) and hip surgery (OR 1.63, 95% CI 1.08-2.48) were more likely to sustain delirium after hip surgery in elderly patients. ASA I and II was less likely to develop delirium after orthopedic surgery (OR 0.52, 95% CI 0.34-0.79).
conclusionsRelated prophylaxis strategies should be implemented in the elderly involved with above-mentioned risk factors to prevent delirium after orthopedic surgery.
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