Trial reportSleep & breathing = Schlaf & Atmung2021
Sleep EEG microstructure is associated with neurobehavioural impairment after extended wakefulness in obstructive sleep apnea.
Trial report in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Paroxysmal slow wave events are associated with cognitive impairment in patients with obstructive sleep apnea.Alzheimer's research & therapy · 2022Trial
- Wake EEG and Sleep Hypoxemia Predicts Poor Driving and Vigilance Following Extended Wakefulness in People With OSA.Journal of sleep research · 2026Article
- Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
- Dynamic brain network modulation by paced breathing and breath-holding: an EEG-based functional connectivity study.Frontiers in physiology · 2025Article
- Article
- Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles.Acta neurologica Belgica · 2024Article
- Article
- Association Between EEG Power During Sleep and Attention Levels in Patients with Major Depressive Disorder.Nature and science of sleep · 2024Article
- Electroencephalographic slowdowns during sleep are associated with cognitive impairment in patients who have obstructive sleep apnea but no dementia.Sleep & breathing = Schlaf & Atmung · 2023Article
- Article
- Sleep Spindle Characteristics and Relationship with Memory Ability in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.Journal of clinical medicine · 2023Article
- New Metrics from Polysomnography: Precision Medicine for OSA Interventions.Nature and science of sleep · 2023Review
- Epidemiology, Physiology and Clinical Approach to Sleepiness at the Wheel in OSA Patients: A Narrative Review.Journal of clinical medicine · 2022Review
- The association between sleep microarchitecture and cognitive function in middle-aged and older men: a community-based cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Electroencephalography Theta/Beta Ratio Decreases in Patients with Severe Obstructive Sleep Apnea.Nature and science of sleep · 2022Article
- New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences.Frontiers in neuroscience · 2021Review
- Electroencephalographic Activity and Cognitive Function in Middle-Aged Patients with Obstructive Sleep Apnea Before and After Continuous Positive Airway Pressure Treatment.Nature and science of sleep · 2021Article
- EEG Power Spectral Analysis of Abnormal Cortical Activations During REM/NREM Sleep in Obstructive Sleep Apnea.Frontiers in neurology · 2021Article
- Obstructive Sleep Apnea and Its Treatment in Aging: Effects on Alzheimer's disease Biomarkers, Cognition, Brain Structure and Neurophysiology.Neurobiology of disease · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeUsing quantitative EEG (qEEG) analysis, we investigated sleep EEG microstructure as correlates of neurobehavioural performance after 24 h of extended wakefulness in untreated OSA.
methodsEight male OSA patients underwent overnight polysomnography (PSG) at baseline followed by 40 h awake with repeated performance testing (psychomotor vigilance task [PVT] and AusEd driving simulator). EEG slowing during REM and spindle density during NREM sleep were calculated using power spectral analysis and a spindle detection algorithm at frontal and central electrode sites. Correlations between sleep EEG microstructure measures and performance after 24-h awake were assessed.
resultsGreater EEG slowing during REM sleep was associated with slower PVT reaction times (rho = - 0.79, p = 0.02), more PVT lapses (rho = 0.87, p = 0.005) and more AusEd crashes (rho = 0.73, p = 0.04). Decreased spindle density in NREM sleep was also associated with slower PVT reaction times (rho = 0.89, p = 0.007). Traditional PSG measures of disease severity were not consistent correlates of neurobehavioural performance in OSA.
conclusionsSleep EEG microstructure measures recorded during routine PSG are associated with impaired vigilance in OSA patients after sleep deprivation. SIGNIFICANCE: Quantitative brain oscillatory (or EEG)-based measures of sleep may better reflect the deleterious effects of untreated OSA than traditional PSG metrics in at-risk individuals. Trial Registration ACTRN12606000066583.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.