Evidence map›Paper›PMID 32772286›Full record

ArticleEnvironmental science and pollution research international2020

Geographical origin differentiation of Chinese Angelica by specific metal element fingerprinting and risk assessment.

Lei Sun, Xiao Ma, Hong-Yu Jin, Chang-Jun Fan, Xiao-Dong Li, Tian-Tian Zuo, Shuang-Cheng Ma, Sicen Wang

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Processing of Angelica (Food science & nutrition · 2024
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lei Sun *School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China.
Xiao Ma *Gansu Institute for Drug Control, Lanzhou, 730070, China.
Hong-Yu JinSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China.
Chang-Jun FanShimadzu China Innovation Center, Shimadzu (China) Co. LTD, Beijing, 100020, China.
Xiao-Dong LiShimadzu China Innovation Center, Shimadzu (China) Co. LTD, Beijing, 100020, China.
Tian-Tian ZuoSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China. zuotiantian2011@163.com.
Shuang-Cheng MaNational Institutes for Food and Drug Control, No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050, China. masc@nifdc.org.cn.
Sicen WangSchool of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China. wangsc@mail.xjtu.edu.cn.
Xi'an Jiaotong University · CNNational Institutes for Food and Drug Control · CNShimadzu (China) · CNGuangdong Institute for Drug Control · CN

Funding

National Major Scientific and Technological Special Project for "Significant New Drugs Development" 2018ZX09735006
6 · The paper itself

Abstract

Traceability offers significant information about the quality and safety of Chinese Angelica, a medicine and food homologous substance. In this study, a systematic four-step strategy, including sample collection, specific metal element fingerprinting, multivariate statistical analysis, and benefit-risk assessment, was developed for the first time to identify Chinese Angelica based on geographical origins. Fifteen metals in fifty-six Chinese Angelica samples originated from three provinces were analyzed. The multivariate statistical analysis model established, involving hierarchical cluster analysis (HCA), principal component analysis (PCA), and self-organizing map clustering analysis was able to identify the origins of samples. Furthermore, benefit-risk assessment models were created by combinational calculation of chemical daily intake (CDI), hazard index (HI), and cancer risk (CR) levels to evaluate the potential risks of Chinese Angelica using as traditional Chinese medicine (TCM) and food, respectively. Our systematic strategy was well convinced to accurately and effectively differentiate Chinese Angelica based on geographical origins.

Indexed as

AngelicaMedicine, Chinese TraditionalMetalsPrincipal Component AnalysisRisk AssessmentMetalsChemometricsChinese AngelicaHazard index (HI)Lifetime cancer risk (CR)Medicine and food homologous substance (MFHS)Risk assessmentSpecific metal element fingerprinting (SMEF)

Identifiers

PMID32772286
OpenAlexW3047726937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.