Evidence map›Paper›PMID 32772162›Full record

Observational studyArchives of dermatological research2021

Association study indicates combined effect of interleukin-10 and angiotensin-converting enzyme in basal cell carcinoma development.

Nikolaos Koronellos, Christos Yapijakis, Alexandros Katoulis, Dimitris Avgoustidis, Antonis Vylliotis, Veronica Papakosta, Stavroula Diamantopoulou, Omiros Zografos, Georgia Vairaktari, Eleftherios Vairaktaris and 1 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Archives of dermatological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Nikolaos KoronellosDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Christos YapijakisDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Alexandros KatoulisDepartment of Dermatology and Venereology, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Dimitris AvgoustidisDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Antonis VylliotisDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Veronica PapakostaDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece. vpapakosta71@gmail.com.ORCID http://orcid.org/0000-0003-4033-1181
Stavroula DiamantopoulouDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Omiros ZografosDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Georgia VairaktariSchool of Medicine, University of Cyprus, Nicosia, Cyprus.
Eleftherios VairaktarisDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Stavros VassiliouDepartment of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokines involved in inflammatory and immune response have been associated with risk for development of basal cell carcinoma (BCC). In this study, three functional DNA polymorphisms affecting gene expression were investigated in 54 BCC patients and 111 healthy controls: interleukin-1b (IL-1b) +3953C/T, interleukin-10 (IL-10) - 1082G/A and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms. Significant increase of the variant alleles was observed in IL-10 - 1082G (P = 0.019) and in ACE D (P = 0.003) in BCC patients in comparison to controls. Multivariate logistic regression models evaluated the contribution of homozygous and heterozygous variant polymorphisms to the risk for BCC development. The studied polymorphisms influencing the expression of IL-10 and ACE genes were recognized as potential predictive factors for BCC. These findings suggest a possible molecular mechanism leading to BCC development that is likely to involve the activation of angiotensin receptors in combination with increased plasma levels of IL-10 in patients.

Indexed as

AdolescentAdultAgedAged, 80 and overAllelesAngiotensinsBasal Cell CarcinomaBiomarkers, TumorCase-Control StudiesFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHealthy VolunteersHumansInterleukin-10MaleACE protein, humanAngiotensinsBiomarkers, TumorIL10 protein, humanInterleukin-10Peptidyl-Dipeptidase AAngiotensin-converting enzymeBasal cell carcinomaInterleukin-10Interleukin-1b

Identifiers

PMID32772162
OpenAlexW3048310896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.