Evidence map›Paper›PMID 32772145›Full record

ArticlePsychopharmacology2020

Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents.

Philip A Spechler, Bader Chaarani, Catherine Orr, Matthew D Albaugh, Nicholas R Fontaine, Stephen T Higgins, Tobias Banaschewski, Arun L W Bokde, Erin Burke Quinlan, Sylvane Desrivières and 18 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. The Developmental Trajectory to Cannabis Use Disorder.The American journal of psychiatry · 2024
    Article
  6. Article
  7. Alcohol and Cannabis Use and the Developing Brain.Alcohol research : current reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Philip A SpechlerVermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05401, USA. philip.spechler@uvm.edu.ORCID http://orcid.org/0000-0003-3833-7672
Bader ChaaraniVermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05401, USA.
Catherine OrrDepartment of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, 05401, USA.
Matthew D AlbaughDepartment of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, 05401, USA.
Nicholas R FontaineDepartment of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, 05401, USA.
Stephen T HigginsVermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05401, USA.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Erin Burke QuinlanCentre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Sylvane DesrivièresCentre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig-Berlin, Germany.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and Psychiatry Department 91G16, Orsay Hospital, Paris, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dimitri Papadopoulos OrfanosDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Tomáš PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Paris, France.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Hugh GaravanVermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05401, USA.

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KHADANGA, SHERRIE · 2013 to 2022
$21.3M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
Development and clinical validation of multimodal risk algorithms for predicting future internalizing psychopathologyK08MH121654 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ALBAUGH, MATTHEW D · 2020 to 2023
$737k
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Medical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM103644NIGMS NIH HHS P20GM103644NIH HHS U54 EB020403NIMH NIH HHS K08 MH121654NIMH NIH HHS R01 MH085772
6 · The paper itself

Abstract

rationaleThe amygdala is a key brain structure to study in relation to cannabis use as reflected by its high-density of cannabinoid receptors and functional reactivity to processes relevant to drug use. Previously, we identified a correlation between cannabis use in early adolescence and amygdala hyper-reactivity to angry faces (Spechler et al. 2015).

objectivesHere, we leveraged the longitudinal aspect of the same dataset (the IMAGEN study) to determine (1) if amygdala hyper-reactivity predicts future cannabis use and (2) if amygdala reactivity is affected by prolonged cannabis exposure during adolescence.

methodsFirst, linear regressions predicted the level of cannabis use by age 19 using amygdala reactivity to angry faces measured at age 14 prior to cannabis exposure in a sample of 1119 participants. Next, we evaluated the time course of amygdala functional development from age 14 to 19 for angry face processing and how it might be associated with protracted cannabis use throughout this developmental window. We compared the sample from Spechler et al. 2015, the majority of whom escalated their use over the 5-year interval, to a matched sample of non-users.

resultsRight amygdala reactivity to angry faces significantly predicted cannabis use 5 years later in a dose-response fashion. Cannabis-naïve adolescents demonstrated the lowest levels of amygdala reactivity. No such predictive relationship was identified for alcohol or cigarette use. Next, follow-up analyses indicated a significant group-by-time interaction for the right amygdala.

conclusions(1) Right amygdala hyper-reactivity is predictive of future cannabis use, and (2) protracted cannabis exposure during adolescence may alter the rate of neurotypical functional development.

Indexed as

AdolescentAdolescent BehaviorAmygdalaFacial RecognitionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMarijuana UseYoung AdultAdolescenceAmygdalaCannabisPredictionRiskSocial threat

Identifiers

PMID32772145
PMCPMC7572697

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