Evidence map›Paper›PMID 32771994›Full record

ArticleJournal for immunotherapy of cancer2020

CD163

Saskia J Santegoets, Chantal L Duurland, Ekaterina J Jordanova, Vanessa J van Ham, Ilina Ehsan, Nikki M Loof, Vipin Narang, Charles A Dutertre, Florent Ginhoux, Sylvia L van Egmond and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Type I conventional dendritic cells and CD8Frontiers in immunology · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Single-cell analysis of myeloid cells in HPVFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Saskia J SantegoetsMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2874-4402
Chantal L DuurlandMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Ekaterina J JordanovaDepartment of Obstetrics and Gynecology, Center for Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC - Locatie VUMC, Amsterdam, Noord-Holland, The Netherlands.
Vanessa J van HamMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Ilina EhsanMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Nikki M LoofMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Vipin NarangSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Charles A DutertreSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Sylvia L van EgmondDepartment of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Marij J P WeltersMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Sjoerd H van der BurgMedical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands shvdburg@lumc.nl.ORCID 0000-0002-6556-0354
Leiden University Medical Center · NLAgency for Science, Technology and Research · SGCentrum voor Gynaecologische Oncologie Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo)radiotherapy than HPV-negative OPSCC, especially in patients with a concomitant intratumoral HPV-specific and type-1 cytokine-oriented T cell response. However, knowledge on the type of myeloid cells and their coordination with intratumoral T cells and influence on patient outcome in OPSCC is lacking.

methodsWe analyzed the presence of intratumoral myeloid cells and their relationship to tumor-infiltrating T cells and patient outcome in a well-described cohort of HPV16

resultsWe show that the tumor microenvironment of HPV16

conclusionsThese data suggest an important role for intratumoral CD163

Indexed as

Antigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenFemaleHuman papillomavirus 16HumansOropharyngeal NeoplasmsPrognosisReceptors, Cell SurfaceT-Lymphocytes, RegulatoryTumor MicroenvironmentAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenReceptors, Cell Surfacedendritic cellshead and neck neoplasmsimmunity, cellularlymphocytes, tumor-infiltratingtumor microenvironment

Identifiers

PMID32771994
PMCPMC7418847
OpenAlexW3048187299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.