Evidence map›Paper›PMID 32771993›Full record

ArticleJournal for immunotherapy of cancer2020

Discovery and validation of surface

Robyn A A Oldham, Mary L Faber, Theodore R Keppel, Amanda R Buchberger, Matthew Waas, Parameswaran Hari, Rebekah L Gundry, Jeffrey A Medin

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mapping the cancer surface proteome in search of target antigens for immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Robyn A A OldhamMedical Biophysics, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Mary L FaberPediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Theodore R KeppelBiochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Amanda R BuchbergerBiochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew WaasBiochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Parameswaran HariDivision of Hematology Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rebekah L GundryBiochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jeffrey A MedinMedical Biophysics, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada jmedin@mcw.edu.
Medical College of Wisconsin · US

Funding

Cell Surface Phenotyping Human Primary CellsR01HL134010 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUNDRY, REBEKAH L. · 2016 to 2020
$1.9M
Cell Surface Proteins in Human CardiomyocytesR01HL126785 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUNDRY, REBEKAH L. · 2016 to 2019
$1.5M
Investigating the Utility and Function of a Novel Cardiomyocyte Cell Surface ProteinF31HL140914 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WAAS, MATTHEW R. · 2018 to 2019
$70k
NHLBI NIH HHS F31 HL140914NHLBI NIH HHS R01 HL126785NHLBI NIH HHS R01 HL134010
6 · The paper itself

Abstract

backgroundMultiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow. While recent advances in treatment for MM have improved patient outcomes, the 5-year survival rate remains ~50%. A better understanding of the MM cell surface proteome could facilitate development of new directed therapies and assist in stratification and monitoring of patient outcomes.

methodsIn this study, we first used a mass spectrometry (MS)-based discovery-driven cell surface capture (CSC) approach to map the cell surface

resultsWe identified 696 MM cell surface

conclusionsThis MM surface

Indexed as

Biomarkers, TumorCell LineFemaleHumansImmunotherapyMaleMembrane GlycoproteinsBiomarkers, TumorMembrane Glycoproteinsantigens, neoplasmhematologic neoplasmsImmunotherapytumor biomarkers

Identifiers

PMID32771993
PMCPMC7418848
OpenAlexW3047919807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.