SynthesisBMJ open2020
Risk factors for pain and functional impairment in people with knee and hip osteoarthritis: a systematic review and meta-analysis.
Synthesis in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06854237 (Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic Factors and Changes in Pain, Physical Functioning, and Participation in Patients With Hip and/or Knee Osteoarthritis: A Systematic Review.Arthritis care & research · 2025Pooled it
- The relationship between MRI-detected hip abnormalities and hip pain in hip osteoarthritis: a systematic review.Rheumatology international · 2024Pooled it
- Impact of preoperative education on early outcomes following hip and knee arthroplasty : a 21,000-patient multicentre NHS analysis.Bone & joint open · 2026Article
- Re-examining the association between region-specific pain recurrence and muscle force strategies in patients with patellofemoral pain via OpenSim and artificial intelligence: a prospective cohort study toward targeted rehabilitation.Journal of neuroengineering and rehabilitation · 2025Article
- Imaging of osteoarthritis-related bone marrow lesions in clinical trials.Osteoarthritis imaging · 2025Article
- Electromyographic Analysis of Thigh Muscle Activity in Arthritic Knees During Sit-to-Stand and Stand-to-Sit Movements: Effects of Seat Height and Foot Position.Healthcare (Basel, Switzerland) · 2025Article
- Progression of Bone Marrow Lesions and the Development of Knee Osteoarthritis: Osteoarthritis Initiative Data.Radiology · 2024Article
- Development and evaluation of nomograms for predicting osteoarthritis progression based on MRI cartilage parameters: data from the FNIH OA biomarkers Consortium.BMC medical imaging · 2023Article
- Influence of physically demanding occupations on the development of osteoarthritis of the hip: a systematic review.Journal of occupational medicine and toxicology (London, England) · 2022Review
- Semi-quantitative magnetic resonance imaging scoring of the knee detects previous injuries in professional soccer players.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Gender-Related Aspects in Osteoarthritis Development and Progression: A Review.International journal of molecular sciences · 2022Review
- Development of medical therapeutics in osteoarthritis: time for action to improve patient care.Rheumatology (Oxford, England) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo identify risk factors for pain and functional deterioration in people with knee and hip osteoarthritis (OA) to form the basis of a future 'stratification tool' for OA development or progression.
designSystematic review and meta-analysis.
methodsAn electronic search of the literature databases, Medline, Embase, CINAHL, and Web of Science (1990-February 2020), was conducted. Studies that identified risk factors for pain and functional deterioration to knee and hip OA were included. Where data and study heterogeneity permitted, meta-analyses presenting mean difference (MD) and ORs with corresponding 95% CIs were undertaken. Where this was not possible, a narrative analysis was undertaken. The Downs & Black tool assessed methodological quality of selected studies before data extraction. Pooled analysis outcomes were assessed and reported using the Grading of Reccomendation, Assessment, Development and Evaluation (GRADE) approach.
results82 studies (41 810 participants) were included. On meta-analysis: there was moderate quality evidence that knee OA pain was associated with factors including: Kellgren and Lawrence≥2 (MD: 2.04, 95% CI 1.48 to 2.81; p<0.01), increasing age (MD: 1.46, 95% CI 0.26 to 2.66; p=0.02) and whole-organ MRI scoring method (WORMS) knee effusion score ≥1 (OR: 1.35, 95% CI 0.99 to 1.83; p=0.05). On narrative analysis: knee OA pain was associated with factors including WORMS meniscal damage ≥1 (OR: 1.83). Predictors of joint pain in hip OA were large acetabular bone marrow lesions (BML; OR: 5.23), chronic widespread pain (OR: 5.02) and large hip BMLs (OR: 4.43).
conclusionsOur study identified risk factors for clinical pain in OA by imaging measures that can assist in predicting and stratifying people with knee/hip OA. A 'stratification tool' combining verified risk factors that we have identified would allow selective stratification based on pain and structural outcomes in OA. PROSPERO REGISTRATION NUMBER: CRD42018117643.
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