Evidence map›Paper›PMID 32771988›Full record

ArticleBMJ open2020

Potentially addictive drugs dispensing to patients receiving opioid agonist therapy: a register-based prospective cohort study in Norway and Sweden from 2015 to 2017.

Jørn Henrik Vold, Christer Aas, Svetlana Skurtveit, Ingvild Odsbu, Fatemeh Chalabianloo, Johan Reutfors, Anne Halmøy, Kjell Arne Johansson, Lars Thore Fadnes

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jørn Henrik VoldDepartment of Addiction Medicine, Haukeland University Hospital, Bergen, Norway jorn.vold@uib.no.ORCID 0000-0001-8701-7638
Christer AasDepartment of Addiction Medicine, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0002-6469-9354
Svetlana SkurtveitDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Ingvild OdsbuDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden.
Fatemeh ChalabianlooDepartment of Addiction Medicine, Haukeland University Hospital, Bergen, Norway.
Johan ReutforsDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden.
Anne HalmøyDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Kjell Arne JohanssonDepartment of Addiction Medicine, Haukeland University Hospital, Bergen, Norway.
Lars Thore FadnesDepartment of Addiction Medicine, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0001-8757-2092
Haukeland University Hospital · NOKarolinska Institutet · SENorwegian Institute of Public Health · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the use of benzodiazepines, z-hypnotics, gabapentinoids, opioids and centrally acting stimulants (CAS) among patients who had received opioid agonist therapy (OAT) in Norway and Sweden during the period 2015 - 2017.

designA register-based prospective cohort study using information about dispensed drugs from the Norwegian Prescription Database and Swedish Prescribed Drug Register.

settingPatients who were dispensed OAT opioids from pharmacies.

participantsA total of 7176 Norwegian and 3591 Swedish patients on OAT were included. OUTCOME MEASURES: The number and frequency of potentially addictive drugs dispensed were calculated for the two countries. The mean daily doses of dispensed benzodiazepines and z-hypnotics were summarised by calculating benzodiazepines in diazepam equivalents and z-hypnotics in zopiclone equivalents.

resultsIn 2017, 46% of patients in Norway, and 15% in Sweden, were dispensed a benzodiazepine. Moreover, 14% in Norway and 26% in Sweden received z-hypnotics. Gabapentinoids were dispensed to 10% of patients in Norway and 19% of patients in Sweden. In Norway, 6% and 12% of the patients received strong and weak non-OAT opioids, respectively, whereas in Sweden 10% were dispensed strong non-OAT opioids and 5% weak non-OAT opioids . CAS were dispensed to 4% in Norway and 18% in Sweden. The mean daily doses of benzodiazepines were 16 and 17 mg diazepam equivalents in Norway and Sweden, respectively. For z-hypnotics, the mean daily dose was 8 mg zopiclone equivalents in both countries. 'Benzodiazepines and z-hypnotics' was the most dispensed drug combination in 2017. Similar results were found in 2015 and 2016.

conclusionsNearly half of those patients who were dispensed an OAT opioid in Norway and Sweden were dispensed potentially addictive drugs. The differences identified between Norway and Sweden might be related to differences in eligibility guidelines and restrictions with respect to OAT.

Indexed as

Analgesics, OpioidPharmaceutical PreparationsBenzodiazepinesDrug PrescriptionsHumansNorwayProspective StudiesSwedenAnalgesics, OpioidBenzodiazepinesPharmaceutical Preparationsepidemiologymental healthsubstance misuse

Identifiers

PMID32771988
PMCPMC7418685
OpenAlexW3048329713

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.