Evidence map›Paper›PMID 32771635›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2020

New loss of smell and taste: Uncommon symptoms in COVID-19 patients on Nord Franche-Comte cluster, France.

Timothée Klopfenstein, Hajer Zahra, N'dri Juliette Kadiane-Oussou, Quentin Lepiller, Pierre-Yves Royer, Lynda Toko, Vincent Gendrin, Souheil Zayet

Abstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 5 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Systematic review and meta-analysis of olfactory and gustatory dysfunction in COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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  10. Prognosis of patients with coronavirus disease with or without anosmia: A systematic review.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025
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  15. Contemporary Analysis of Olfactory Dysfunction in Mild to Moderate Covid 19 Patients in A Tertiary Health Care Centre.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Timothée KlopfensteinInfectious Disease Department, Nord Franche-Comté Hospital, France. Electronic address: timothee.klopfenstein@hnfc.fr.
Hajer ZahraDiabetology Department Nord Franche-Comté Hospital, France.
N'dri Juliette Kadiane-OussouInfectious Disease Department, Nord Franche-Comté Hospital, France.
Quentin LepillerVirology Department, Centre-Hospitalier Universitaire de Besançon, France.
Pierre-Yves RoyerInfectious Disease Department, Nord Franche-Comté Hospital, France.
Lynda TokoInfectious Disease Department, Nord Franche-Comté Hospital, France.
Vincent GendrinInfectious Disease Department, Nord Franche-Comté Hospital, France.
Souheil ZayetInfectious Disease Department, Nord Franche-Comté Hospital, France. Electronic address: souhail.zayet@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew loss of smell or taste was not included as common symptoms of COVID-19 until March 2020 when the pandemic started in Western countries. We want to describe the prevalence and features of anosmia and dysgeusia in COVID-19 patients.

methodsWe retrospectively investigated the clinical features of confirmed cases of COVID-19 in Nord Franche-Comté Hospital, Trevenans, France, between March, 1st and March, 14th 2020. We used SARS-CoV-2 real time RT-PCR in respiratory samples to confirm the cases.

resultsOf 70 patient enrolled, the mean age was 57.0 years and 29 patients (41%) were men. Median Charlson comorbidity index was 1.70(±2.5). Twenty-seven (39%) patients had pneumonia. Fatigue (93% [65]), cough (80% [55]) and fever (77% [54]) were the three main symptoms. Neurologic symptoms were present in more than half of the patients: anosmia (53% [37]) and dysgeusia (48% [34]). The mean duration of anosmia was 7.4 (±5, [1-21]) days, 51% (36/70) recovered before 28 days of evolution. Only one patient with anosmia had not recovered at the end of the follow-up. Patients with anosmia had less often a pneumonia (10/37 vs 17/33, p = 0.036), were less often hospitalized (13/37 vs 20/33, p = 0.033) and needed less often oxygen therapy (6/37 vs 17/33, p = 0.002) than patients without anosmia. There were no statistically differences for viral load between patients with anosmia and patients without anosmia (5.5 [2.0-8.6] vs 5.3 [2.1-8.5] log copies/ml respectively, p = 0.670). The fatality of COVID-19 in our study was 6% with four deaths.

conclusionsAnosmia and dysgeusia are present in half of COVID-19 patients. The mean duration of anosmia was 7 days and the outcome seems favorable in less than 28 days.

Indexed as

BetacoronavirusAdultCoronavirus InfectionsCOVID-19DysgeusiaFemaleFranceHumansMaleMiddle AgedOlfaction DisordersPandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2Time FactorsAnosmiaClinical featuresCoronavirus disease 2019DysgeusiaSymptoms

Identifiers

PMID32771635
PMCPMC7410813

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.