ReviewThe American journal of medicine2021
Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection.
Review in The American journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04729140 (A Randomized Double-blinded Placebo-controlled Outpatient Clinical Trial in High Risk Population Confirmed COVID-19 Patients Using Ivermectin and Doxycycline to Prevent COVID-19 Illness-related Hospitalization), which is not on this map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Double-blinded Placebo-controlled Outpatient Clinical Trial in High Risk Population Confirmed COVID-19 Patients Using Ivermectin and Doxycycline to Prevent COVID-19 Illness-related Hospitalization (COVIVER-OUT PLUS)
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk factors for mortality in COVID-19 patients in sub-Saharan Africa: A systematic review and meta-analysis.PloS one · 2022Pooled it
- The military as a neglected pathogen transmitter, from the nineteenth century to COVID-19: a systematic review.Global health research and policy · 2021Pooled it
- Colchicine for the treatment of COVID-19.The Cochrane database of systematic reviews · 2021Pooled it
- Eccentric cycling is superior to standard rehabilitation for Post-ICU recovery in COVID-19 survivors.PloS one · 2026Trial
- Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial.International journal of general medicine · 2021Trial
- A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19.Antimicrobial agents and chemotherapy · 2020Trial
- Article
- Article
- Is Covid-19 "vaccine uptake" in postsecondary education a "problem"? A critical policy inquiry.Health (London, England : 1997) · 2024Article
- Determinants of COVID-19 vaccine-induced myocarditis.Therapeutic advances in drug safety · 2024Article
- Combination of spironolactone and sitagliptin improves clinical outcomes of outpatients with COVID-19: a prospective cohort study.Journal of endocrinological investigation · 2024Observational
- Is resistance to Covid-19 vaccination a "problem"? A critical policy inquiry of vaccine mandates for healthcare workers.AIMS public health · 2024Article
- Home-based initiatives for acute management of COVID-19 patients needing oxygen: differences across The Netherlands.BMC health services research · 2023Article
- Observational
- Multidisciplinary recommendations for the management of CAR-T recipients in the post-COVID-19 pandemic era.Experimental hematology & oncology · 2023Review
- Suggestions on home quarantine and recovery of novel coronavirus patients.Journal of translational internal medicine · 2023Article
- Article
- Prolonged SARS-CoV-2 infection during autologous hematopoietic stem cell transplantation from Hodgkin's lymphoma: a case report.The Pan African medical journal · 2023Article
- Appraising the decision-making process concerning COVID-19 policy in postsecondary education in Canada: A critical scoping review protocol.AIMS public health · 2023Article
- Steroid in the Treatment of Outpatient COVID-19: A Multicenter Randomized Controlled Trial.Advanced biomedical research · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital. In the absence of clinical trial results, physicians must use what has been learned about the pathophysiology of SARS-CoV-2 infection in determining early outpatient treatment of the illness with the aim of preventing hospitalization or death. This article outlines key pathophysiological principles that relate to the patient with early infection treated at home. Therapeutic approaches based on these principles include 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy, and 5) administration of oxygen, monitoring, and telemedicine. Future randomized trials testing the principles and agents discussed will undoubtedly refine and clarify their individual roles; however, we emphasize the immediate need for management guidance in the setting of widespread hospital resource consumption, morbidity, and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.