ArticleEnvironmental health and preventive medicine2020
Association between metal cobalt exposure and the risk of congenital heart defect occurrence in offspring: a multi-hospital case-control study.
Article in Environmental health and preventive medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence.Pediatric cardiology · 2025Pooled it
- Prenatal exposure to vanadium and lead and its impact on the risk of congenital heart defects in neonates: evidence from the Lanzhou Birth Cohort.Frontiers in public health · 2026Article
- Environmental Risk in American Indian Children, Including Cardiovascular and Hematologic Consequences of Cadmium Exposure: Possible Means of Mitigation.International journal of environmental research and public health · 2025Review
- Prenatal exposure to barium and arsenic and the odds of congenital heart defects in offspring: a nested case-control study within a birth cohort in Lanzhou, China.Frontiers in public health · 2025Article
- Review
- Prenatal Parental Exposure to Metals and Birth Defects: A Prospective Birth Cohort Study.Environmental science & technology · 2024Article
- Assessment of Human Health Risk Indices Due to Metal Contamination in the Surface Water of the Negro River Sub-Basin, Áncash.International journal of environmental research and public health · 2024Article
- Relationship between pregnant women's combined exposure to heavy metals and their offspring's congenital heart defects in Lanzhou, China.Frontiers in pediatrics · 2024Article
- Heavy Metals in Foods and Beverages: Global Situation, Health Risks and Reduction Methods.Foods (Basel, Switzerland) · 2023Review
- Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMany studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between cobalt exposure and CHD occurrence in offspring. The aim of this study was to analyze the association between cobalt exposure in mothers and the risk of CHDs in offspring. MATERIALS AND
methodsIn order to explore the association between cobalt exposure and occurrence of congenital heart defect (CHD), a case-control study with 490 controls and 399 cases with CHDs in China were developed. The concentrations of cobalt in hair of pregnant woman and fetal placental tissue were measured and processed by a logistic regression analysis to explore the relationship between cobalt exposure and risk of CHDs.
resultsThe median concentration of hair cobalt in the control and case group was 0.023 ng/mg and 0.033 ng/mg (aOR, 1.837; 95% CI, 1.468-2.299; P < 0.001), respectively. And the median (5-95% range) fetal placental cobalt concentrations were 19.350 ng/g and 42.500 ng/g (aOR, 2.924; 95% CI, 2.211-3.868; P < 0.001) in the control and case groups, respectively. Significant differences in the middle level of cobalt in hair were found in the different CHD subtypes, including septal defects, conotruncal defects, right ventricular outflow tract obstruction, and left ventricular outflow tract obstruction (P < 0.001). Dramatically, different cobalt concentrations in fetal placental tissue were found in all subtypes of cases with CHDs (P < 0.01).
conclusionsThe finding suggested that the occurrence of CHDs may be associated with cobalt exposure.
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