ArticleMolecular medicine (Cambridge, Mass.)2020
The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity.
Article in Molecular medicine (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 25 citations in OpenAlex.
- Nutraceuticals as modulators of genetic, epigenetic and hormonal factors in obesity.European journal of clinical nutrition · 2026Review
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- Phenotypic and genomic frameworks for precision pharmacotherapy in obesity: a narrative review.Frontiers in medicine · 2026Review
- Understanding food addiction in obesity: a genetic perspective.Journal of eating disorders · 2025Article
- Research progress on the mechanistic impact of single-nucleotide polymorphisms and dietary pattern interactions on overweight and obesity in Chinese adults: a narrative review.Frontiers in nutrition · 2025Review
- Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty.Pediatric research · 2024Article
- FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery.JCI insight · 2024Article
- Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China.BMC public health · 2024Article
- Predisposition of the CommonGenes · 2023Article
- Adipose Tissue Hyperplasia and Hypertrophy in Common and Syndromic Obesity-The Case of BBS Obesity.Nutrients · 2023Review
- Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/nearChildren (Basel, Switzerland) · 2023Article
- Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review.Frontiers in endocrinology · 2023Article
- Are there any interactions between modified Nordic-style diet score and MC4R polymorphism on cardiovascular risk factors among overweight and obese women? A cross-sectional study.BMC endocrine disorders · 2022Article
- Associations between KCNQ1 and ITIH4 gene polymorphisms and infant weight gain in early life.Pediatric research · 2022Article
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- Characterization of Single Nucleotide Variants ofJID innovations : skin science from molecules to population health · 2021Article
- Relationship Between Serum Amyloid A1 (Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the correlation between the melanocortin 4 receptor gene (MC4R) single nucleotide polymorphisms (SNPs) and the risk of obesity. This research sought to test the MC4R rs17782313, rs476828 and rs12970134 SNPs, their haplotypes and gene-environment interactions on the risk of obesity in the Maonan ethnic group, an isolated minority in China.
methodsA case-control study comprised of 1836 participants (obesity group, 858; and control group, 978) was conducted. Genotypes of the three SNPs were determined by the next-generation sequencing (NGS) technology.
resultsThe genotypic frequencies of the three SNPs were different between the obesity and control groups (P < 0.05 for all). The minor allelic frequency of the MC4R rs17782313C, rs476828C and rs12970134A was higher in obesity than in control groups (13.8% vs. 8.3%, P < 0.001, 17.1% vs. 10.9%, P < 0.001; and 15.5% vs. 11.5%, P < 0.001; respectively). Additionally, the dominant model of rs17782313 and rs476828 SNPs revealed an increased morbidity function on the risk of obesity (P < 0.05). A correlation between SNP-environment and the risk of obesity was also observed. The rs17782313C-rs476828C-rs12970134A haplotype was associated with high risk of obesity (OR = 1.796, 95% CI = 1.447-2.229), whereas the rs17782313T-rs476828T-rs12970134G and rs17782313T-rs476828T-rs12970134A haplotypes were associated with low risk of obesity (OR = 0.699, 95% CI = 0.586-0.834 and OR = 0.620, 95% CI = 0.416-0.925; respectively). The interactions between haplotype and waist circumference on the risk of obesity were also noted.
conclusionsWe discovered that the MC4R rs17782313, rs476828 and rs12970134 SNPs and their haplotypes were associated with the risk of obesity in the Chinese Maonan population.
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