Evidence map›Paper›PMID 32770719›Full record

ArticleFEBS open bio2020

Curcumin attenuates angiotensin II-induced podocyte injury and apoptosis by inhibiting endoplasmic reticulum stress.

Nan Yu, Lin Yang, Lilu Ling, Yuan Liu, Ying Yu, Qing Wu, Yong Gu, Jianying Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. [Potential of early diagnosis and targeted therapy for Klotho protein in chronic kidney disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  3. Article
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  6. Early Diagnosis and Treatment of Kidney Injury: A Focus on Urine Protein.International journal of molecular sciences · 2024
    Review
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  9. Store-operated CaAmerican journal of physiology. Renal physiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nan YuDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Lin YangDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Lilu LingDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yuan LiuDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Ying YuDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Qing WuDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yong GuDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Jianying NiuDepartment of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6343-2319
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Podocytes are an important component of the glomerular filtration barrier in the kidneys. The dysfunction and apoptosis of podocytes are important factors that can lead to the progression of chronic kidney disease (CKD). In CKD, angiotensin II is continuously elevated in circulation and is considered to have key roles in inducing podocyte injury and apoptosis. Curcumin is a hydrophobic polyphenolic compound extracted from turmeric. Increasing evidence demonstrates that curcumin has a protective effect on the kidneys in CKD. However, the mechanisms mediating this protective effect remain unclear. The aim of this study was to explore whether curcumin could protect against angiotensin II-induced injury and apoptosis of podocytes. We performed western blotting, immunofluorescence, phalloidin staining, and terminal deoxynucleotidyl transferase nick-end labeling staining to observe the expression level of podocyte-specific proteins, apoptosis-related proteins, and the arrangement of F-actin. We found that curcumin could reverse angiotensin II-induced podocyte injury and apoptosis in a dose-dependent manner. In addition, curcumin dose-dependently attenuated a pro-apoptotic pathway, activated by angiotensin II-induced endoplasmic reticulum stress. Conversely, the protective effects of curcumin were impaired upon addition of tunicamycin, an activator of endoplasmic reticulum stress. Thus, we speculate that curcumin protects against angiotensin II-induced podocyte injury and apoptosis, at least partly by inhibiting endoplasmic reticulum stress.

Indexed as

Angiotensin IIAnimalsApoptosisCell LineCells, CulturedChinaCurcuminEndoplasmic ReticulumEndoplasmic Reticulum StressKidneyMiceOxidative StressPodocytesReactive Oxygen SpeciesAngiotensin IICurcuminReactive Oxygen Speciesangiotensin IICKDcurcuminER stresspodocyte

Identifiers

PMID32770719
PMCPMC7530386
OpenAlexW3047626186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.