ArticleJournal of cellular and molecular medicine2020
ICAM-1 and MKL-1 polymorphisms impose considerable impacts on coronary heart disease occurrence.
Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Circulating brain-derived neurotrophic factor dysregulation and its linkage with lipid level, stenosis degree, and inflammatory cytokines in coronary heart disease.Journal of clinical laboratory analysis · 2022Article
- SIRT6 mediates MRTF-A deacetylation in vascular endothelial cells to antagonize oxLDL-induced ICAM-1 transcription.Cell death discovery · 2022Article
- ICAM-1 and MKL-1 polymorphisms impose considerable impacts on coronary heart disease occurrence.Journal of cellular and molecular medicine · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
This study was aimed to explore the correlation of intercellular adhesion molecule-1 (ICAM-1) K469E and megakaryoblastic leukaemia factor-1 (MKL-1) -184C/T polymorphisms with the susceptibility to coronary heart disease (CHD) in the Chinese Han population. 100 CHD patients and 91 healthy people that had no blood connection with each other were enrolled in this case-control study. ICAM-1 and MKL-1 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Multiple logistic regression was used to analyse the correlation between polymorphisms of ICAM-1 and MKL-1 and CHD susceptibility. Differences of genotype and allele frequencies of the two SNPs between case and control groups were analysed by chi-square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were indicated relative susceptibility of CHD. The distributions of ICAM-1 and MKL-1 polymorphisms in each group conformed to Hardy-Weinberg equilibrium (HWE). After adjusting for traditional risk factors, the TT genotype frequency of MKL-1 -184C/T polymorphism was found significantly higher in case group than in control group (P < .05). Meanwhile, T allele frequency increased in case group compared with control group, and the differences had statistical significance (P = .04, OR = 2.34, 95% CI = 1.34-5.26). Logistic regression analysis in this study proved that smoking, hypertension, diabetes and triglyceride (TG) were all risk factors for CHD ICAM-1 K469E polymorphism has no association with the onset of CHD. But MKL-1 -184C/T polymorphism is associated with the risk of CHD and T allele might be a susceptibility factor for CHD.
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