Evidence map›Paper›PMID 32770582›Full record

ReviewMicroscopy research and technique2020

Elucidating the microscopic and computational techniques to study the structure and pathology of SARS-CoVs.

Sindhoora Kaniyala Melanthota, Soumyabrata Banik, Ishita Chakraborty, Sparsha Pallen, Dharshini Gopal, Shweta Chakrabarti, Nirmal Mazumder

Abstract readReview
In one paragraph

Review in Microscopy research and technique, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sindhoora Kaniyala MelanthotaDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.ORCID https://orcid.org/0000-0002-1546-8226
Soumyabrata BanikDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.ORCID https://orcid.org/0000-0002-2254-1428
Ishita ChakrabortyDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Sparsha PallenDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Dharshini GopalDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Shweta ChakrabartiDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Nirmal MazumderDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.ORCID https://orcid.org/0000-0001-8068-6484

Funding

Science and Engineering Research Board ECR/2016/001944
6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoVs), causative of major outbreaks in the past two decades, has claimed many lives all over the world. The virus effectively spreads through saliva aerosols or nasal discharge from an infected person. Currently, no specific vaccines or treatments exist for coronavirus; however, several attempts are being made to develop possible treatments. Hence, it is important to study the viral structure and life cycle to understand its functionality, activity, and infectious nature. Further, such studies can aid in the development of vaccinations against this virus. Microscopy plays an important role in examining the structure and topology of the virus as well as pathogenesis in infected host cells. This review deals with different microscopy techniques including electron microscopy, atomic force microscopy, fluorescence microscopy as well as computational methods to elucidate various prospects of this life-threatening virus.

Indexed as

AnimalsChlorocebus aethiopsComputational BiologyCoronavirus InfectionsHost-Pathogen InteractionsHumansMicroscopyMicroscopy, Atomic ForceMicroscopy, ElectronMicroscopy, Electron, ScanningMicroscopy, FluorescenceSevere acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusVero CellsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2atomic force microscopycomputational biologycoronaviruselectron microscopyfluorescence microscopy

Identifiers

PMID32770582
PMCPMC7436590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.