Evidence map›Paper›PMID 32770488›Full record

Observational studyDigestive diseases and sciences2021

High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California.

Tse-Ling Fong, Brian T Lee, Mimi Chang, Khishigsuren Nasanbayar, Enkhjargal Tsogtoo, Delgerbat Boldbaatar, Esugen D Dashdorj, Namuun E Clifford, Arghun N Dashdorj, Bo-Ram Bang and 9 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cost-Effectiveness of One-time Universal Testing for Hepatitis D Among Adults With Chronic Hepatitis B in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  7. Review
  8. Review
  9. Hepatitis Delta Infection: A Clinical Review.Seminars in liver disease · 2023
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Tse-Ling Fong *Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 2nd Floor, Los Angeles, CA, 90033, USA.
Brian T LeeDivision of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 2nd Floor, Los Angeles, CA, 90033, USA.
Mimi ChangAsian Pacific Liver Center, St. Vincent Medical Center, Los Angeles, CA, USA.
Khishigsuren NasanbayarOnom Foundation, 3 Governance Academy Street, 15th Khoroo, Khan-Uul District, Ulaanbaatar, 17013-0017, Mongolia.
Enkhjargal TsogtooThe Liver Center, 31 UNESCO Street, Dalai Tower 1st Khoroo, Sukhbaatar District, Ulaanbaatar, 14230, Mongolia.
Delgerbat BoldbaatarThe Liver Center, 31 UNESCO Street, Dalai Tower 1st Khoroo, Sukhbaatar District, Ulaanbaatar, 14230, Mongolia.
Esugen D DashdorjThe Liver Center, 31 UNESCO Street, Dalai Tower 1st Khoroo, Sukhbaatar District, Ulaanbaatar, 14230, Mongolia.
Namuun E CliffordOnom Foundation, 3 Governance Academy Street, 15th Khoroo, Khan-Uul District, Ulaanbaatar, 17013-0017, Mongolia.
Arghun N DashdorjThe Liver Center, 31 UNESCO Street, Dalai Tower 1st Khoroo, Sukhbaatar District, Ulaanbaatar, 14230, Mongolia.
Bo-Ram BangDivision of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 2nd Floor, Los Angeles, CA, 90033, USA.
Takeshi ChidaDivision of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 2nd Floor, Los Angeles, CA, 90033, USA.
Carolina LimAsian Pacific Liver Center, St. Vincent Medical Center, Los Angeles, CA, USA.
Masaya SugiyamaGenome Medical Sciences Project, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan.
Masashi MizokamiGenome Medical Sciences Project, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan.
Naranjargal J DashdorjOnom Foundation, 3 Governance Academy Street, 15th Khoroo, Khan-Uul District, Ulaanbaatar, 17013-0017, Mongolia.
Ping LiuDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jeffrey S GlennDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Naranbaatar D Dashdorj *Onom Foundation, 3 Governance Academy Street, 15th Khoroo, Khan-Uul District, Ulaanbaatar, 17013-0017, Mongolia.
Takeshi Saito *Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 2nd Floor, Los Angeles, CA, 90033, USA. saitotak@usc.edu.ORCID 0000-0002-6165-664X
University of Southern California · USNational Center for Global Health and Medicine · JPStanford University · USSt Vincent Medical Center · US

Funding

Impact of Occult Hepatitis C Virus Infection in Progression of Liver DiseasesR21AI139954 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SAITO, TAKESHI · 2018 to 2019
$454k
NIAID NIH HHS R21 AI139954
6 · The paper itself

Abstract

backgroundMongolia is a highly endemic region for chronic hepatitis B (HBV), hepatitis delta (HDV), and hepatitis C (HCV) infections. Aim of this study was to comprehensively characterize chronic viral hepatitis among Mongols living in Southern California.

methodsThree screening events were conducted between August and November 2018, with 528 adult Mongols tested for HBV and HCV. HBsAg (+) individuals (CHB) underwent additional testing for HDV RNA and anti-HDV. Liver tests, platelet count, and FibroScan™ were performed on CHB and chronic HCV (CHC) individuals.

resultsFifty-one out of 534 were HBsAg reactive (9.7%), and all were foreign-born. Mean age of CHB individuals was 37.8 (range 18-69) years. Forty-six out of 51 were HBeAg (-). HBV genotypes were exclusively D2 or A1. Twenty-one out of 51 (41.2%) were anti-HDV (+) and 17/51 (33.3%) were HDV RNA (+). HDV RNA (+) individuals had significantly higher ALT, fibrosis-4 score, and liver stiffness compared to HDV RNA (-) individuals. Incidence of advanced fibrosis was higher in HDV RNA (+) individuals (57% vs. 13%, p = 0.013). Forty-eight (9.1%) individuals were anti-HCV (+) and 19 (3.6%) were HCV RNA (+). Mean age of CHC individuals was 40.2 (range 28-71) years. Prevalence of anti-HCV (+) was higher among those born between 1945 and 1965 versus those born after 1965 (18.8% vs. 7.9%, p = 0.025). Genotype 1b was predominant. Incidence of cirrhosis was 7% among all participants.

conclusionsMongols living in the USA are at high risk for CHB and CHC infections. One-third of CHB individuals had CHD superinfection with advanced fibrosis. Universal screening for viral hepatitis in Mongols in the USA is mandatory.

Indexed as

AdolescentAdultAgedAntibodies, ViralAsian PeopleCross-Sectional StudiesFemaleGenotypeHepatitis B, ChronicHepatitis B virusHepatitis C, ChronicHepatitis D, ChronicHumansLiver CirrhosisMaleMiddle AgedAntibodies, ViralRNA, ViralCirrhosisFatty liverHepatitis BHepatitis CHepatitis delta

Identifiers

PMID32770488
PMCPMC7868472
OpenAlexW3048230411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.