Evidence map›Paper›PMID 32770452›Full record

ArticleMolecular neurobiology2020

Lack of Astrocytic Glycogen Alters Synaptic Plasticity but Not Seizure Susceptibility.

Jordi Duran, M Kathryn Brewer, Arnau Hervera, Agnès Gruart, Jose Antonio Del Rio, José M Delgado-García, Joan J Guinovart

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Glycogen supports glycolytic plasticity in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Neurological glycogen storage diseases and emerging therapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. The multifaceted roles of the brain glycogen.Journal of neurochemistry · 2024
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jordi DuranInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain. jordi.duran@irbbarcelona.org.ORCID http://orcid.org/0000-0002-8342-4882
M Kathryn BrewerInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.
Arnau HerveraInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.
Agnès GruartDivision of Neurosciences, Pablo de Olavide University, Seville, Spain.
Jose Antonio Del RioInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.
José M Delgado-GarcíaDivision of Neurosciences, Pablo de Olavide University, Seville, Spain.
Joan J GuinovartInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.
Biomedical Research Networking Center on Neurodegenerative Diseases · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESUniversidad Pablo de Olavide · ESInstitute for Research in Biomedicine · ES

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
Brain Glycogen-Metabolism,Mechanisms, and Therapeutic PotentialR35NS116824 · NINDS · UNIVERSITY OF KENTUCKY · PI Matthew S. Gentry · 2020 to 2026
$8.2M
Agencia Estatal de Investigación BFU2017-82375-RAgencia Estatal de Investigación BFU2017-84345-PAgencia Estatal de Investigación RTI2018-099773-B-I00"la Caix a" Foundation 100010434NINDS NIH HHS P01 NS097197NINDS NIH HHS P01NS097197NINDS NIH HHS R35 NS116824
6 · The paper itself

Abstract

Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons. By conditional deletion of glycogen synthase (GYS1), we previously developed a mouse model entirely devoid of glycogen in the central nervous system (GYS1

Indexed as

AnimalsAstrocytesDisease SusceptibilityElectrophysiological PhenomenaFemaleGlial Fibrillary Acidic ProteinGlycogenHippocampusKainic AcidMaleMice, KnockoutNeuronal PlasticitySeizuresGlial Fibrillary Acidic ProteinGlycogenKainic AcidAstrocyteEpilepsyGlycogenLong-term potentiationMetabolismPlasticity

Identifiers

PMID32770452
PMCPMC7530046
OpenAlexW3048321846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.