Evidence map›Paper›PMID 32770440›Full record

ArticleEndocrine2021

Cause-specific mortality after diagnosis of thyroid cancer: a large population-based study.

Binbin Du, Fang Wang, Leiming Wu, Zheng Wang, Dianhong Zhang, Zhen Huang, Lu Gao, Yapeng Li, Cui Liang, Pengcheng Li and 1 more

Abstract read
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In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Binbin Du *Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Fang Wang *Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Leiming WuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zheng WangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Dianhong ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhen HuangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Lu GaoDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yapeng LiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Cui LiangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Pengcheng LiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Rui YaoDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. yaorui6@126.com.ORCID 0000-0001-5257-0759
First Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CN

Funding

Henan Province Health Planning Technology Talents Overseas Research Project HWYX2019045
6 · The paper itself

Abstract

purposeThe study aimed to disclose mortality pattern and quantitatively evaluate risks for cause-specific mortality among thyroid cancer survivors.

methodsWe included 173,710 patients from the Surveillance, Epidemiology, and End Results (SEER) database with thyroid cancer diagnosed between 1975 and 2015. Standardized mortality ratio (SMR) was calculated using general US population as the reference. Cumulative incidence function curves were constructed to elaborate crude cause-specific mortality by histology. Cox proportional hazards regression model was adopted to identify predictors for cause-specific mortality, expressed as hazard ratio (HR) and 95% confidence interval (CI).

resultsAfter a median follow-up of 101 months, 23,040 (13.3%) deaths occurred, of which 29.1% and 21.7% were attributable to thyroid cancer and cardiovascular disease (CVD), respectively. CVD SMRs were 1.14, 1.47, 1.21, and 5.66 in patients with follicular, Hürthle cell, medullary and anaplastic histology, respectively. The adjusted HRs of thyroid cancer-specific mortality were 1.59 (95% CI: 1.46-1.74), 1.87 (95% CI: 1.65-2.12), 3.66 (95% CI: 3.31-4.05), and 12.65 (95% CI: 11.50-13.92) for follicular, Hürthle cell, medullary, and anaplastic histology, respectively, as compared with papillary histology; HRs of CVD-specific mortality were 1.23 (95% CI: 1.12-1.34), 1.27 (95% CI: 1.11-1.46), 1.13 (95% CI: 0.96-1.33), and 1.60 (95% CI: 1.19-2.16), respectively. Older age, male sex, nonwhite race, unmarried status, and advanced stage were independent predictors of CVD-specific mortality, while receiving surgery and radiotherapy were protective against CVD-specific mortality.

conclusionsWe disclosed distinct mortality patterns by histology and identified predictors of CVD-specific mortality in thyroid cancer survivors, supporting CVD intervention for aggressive thyroid cancer.

Indexed as

Cancer SurvivorsCardiovascular DiseasesThyroid NeoplasmsAgedCause of DeathHumansMaleRisk FactorsCardiovascular disease(s)Competing-risk analysisMortalitySurvival analysisThyroid cancer

Identifiers

PMID32770440
OpenAlexW3048338053

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.