ArticleClinical research in cardiology : official journal of the German Cardiac Society2021
Association between right-sided cardiac function and ultrasound-based pulmonary congestion on acutely decompensated heart failure: findings from a pooled analysis of four cohort studies.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Advances in Congestion Assessment in Decompensated Heart Failure.Cardiac failure review · 2026Review
- Unveiling the Systemic Impact of Congestion in Heart Failure: A Narrative Review of Multisystem Pathophysiology and Clinical Implications.Journal of cardiovascular development and disease · 2025Review
- Ventricular-Arterial Coupling in Heart Failure with Preserved Ejection Fraction: A Bibliometric Review and Clinical Implications.Cardiac failure review · 2025Review
- A machine learning-based lung ultrasound algorithm for the diagnosis of acute heart failure.Internal and emergency medicine · 2024Article
- Application of an echocardiographic index to characterize right ventricular-pulmonary arterial coupling in heart failure.ESC heart failure · 2024Review
- The Congestion "Pandemic" in Acute Heart Failure Patients.Biomedicines · 2024Review
- Patient phenotype profiling using echocardiography and natriuretic peptides to personalise heart failure therapy.Heart failure reviews · 2024Review
- Lung ultrasound in acute and chronic heart failure: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI).European heart journal. Cardiovascular Imaging · 2023Article
- Exercise-induced B-lines for the diagnosis of heart failure with preserved ejection fraction: a two-centre study.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Right ventricular failure in left heart disease: from pathophysiology to clinical manifestations and prognosis.Heart failure reviews · 2023Review
- Tricuspid annular plane systolic excursion/mitral annular plane systolic excursion ratio in critically ill patients: an index of right- and left-ventricular function mismatch and a risk factor for cardiogenic pulmonary edema.BMC anesthesiology · 2023Observational
- Adaptive versus maladaptive right ventricular remodelling.ESC heart failure · 2023Review
- Association between the Length of Hospital Stay and 30-Day Outcomes in Patients Admitted with Acute Decompensated Heart Failure.Emergency medicine international · 2023Article
- Right ventricular performance in patients with heart failure with mildly reduced ejection fraction: the forgotten ventricle.The international journal of cardiovascular imaging · 2022Article
- Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement.The international journal of cardiovascular imaging · 2022Article
- Improving the EHMRG Prognostic Evaluation of Acute Heart Failure with TAPSE/PASp: A Sequential Approach.Diagnostics (Basel, Switzerland) · 2022Article
- Incremental prognostic value of lung ultrasound on contemporary heart failure risk scores.Frontiers in physiology · 2022Article
- Prognostic Value of Lung Ultrasound in Aortic Stenosis.Frontiers in physiology · 2022Article
- Lung ultrasound in outpatients with heart failure: the wet-to-dry HF study.ESC heart failure · 2021Article
- Exercise-induced B-lines in heart failure with preserved ejection fraction occur along with diastolic function worsening.ESC heart failure · 2021Article
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Authors and funding
15 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRight ventricular (RV) dysfunction and RV-pulmonary artery (PA) uncoupling are associated with the development of pulmonary congestion during exercise. However, there is limited information regarding the association between these right-sided cardiac parameters and pulmonary congestion in acutely decompensated heart failure (HF).
methodsWe performed an individual patient meta-analysis from four cohort studies of hospitalized patients with HF who had available lung ultrasound (B-lines) data on admission and/or at discharge. RV function was assessed by tricuspid annular plane systolic excursion (TAPSE), RV-PA coupling was defined as the ratio of TAPSE to PA systolic pressure (PASP).
resultsAdmission and discharge cohort included 319 patients (75.8 ± 10.1 years, 46% women) and 221 patients (77.9 ± 9.0 years, 47% women), respectively. Overall, higher TAPSE was associated with higher ejection fraction, lower PASP, b-type natriuretic peptide and B-line counts. By multivariable analysis, worse RV function or RV-PA coupling was associated with higher B-line counts on admission and at discharge, and with a less reduction in B-line counts from admission to discharge. Higher B-line counts at discharge were associated with a higher risk of the composite of all-cause mortality and/or HF re-hospitalization [adjusted-HR 1.13 (1.09-1.16), p < 0.001]. Furthermore, the absolute risk increase related to high B-line counts at discharge was higher in patients with lower TAPSE.
conclusionsIn patients with acutely decompensated HF, impaired RV function and RV-PA coupling were associated with severe pulmonary congestion on admission, and less resolution of pulmonary congestion during hospital stay. Worse prognosis related to residual pulmonary congestion was enhanced in patients with RV dysfunction. TAPSE, tricuspid annular plane systolic excursion; PASP, pulmonary artery systolic pressure.
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