Evidence map›Paper›PMID 32770356›Full record

SynthesisEuropean journal of nutrition2021

An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer.

Jakub Morze, Anna Danielewicz, Katarzyna Przybyłowicz, Hongmei Zeng, Georg Hoffmann, Lukas Schwingshackl

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07007169 (Mediterranean Diet and Inequality in Early Breast Cancer), which is not on this map. Cited by 183 papers, 28 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 28 pooled it
30.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07007169 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Mediterranean Diet and Inequality in Early Breast Cancer: A Multicenter Randomized Clinical Trial

TypeinterventionalSponsorEsbjerg Hospital - University Hospital of Southern DenmarkRan2025 to 2036Enrolled105ConditionsEarly Breast CancerArmsThe goal is daily consumption of a minimum of 30 grams of dietary fiber and weekly consumption of a minimum of 30 different plant foods, minimizing the amount of ultra-processed food., Standard Diet
3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 28 syntheses or guidelines pooled it, 341 citations in OpenAlex.

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  8. Association between priori and posteriori dietary patterns and gastric cancer risk: an updated systematic review and meta-analysis of observational studies.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025
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  20. Adherence to Mediterranean Diet and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Jakub MorzeDepartment of Cardiology and Internal Diseases, University of Warmia and Mazury, al. Warszawska 30, 10-082, Olsztyn, Poland. jakub.morze@uwm.edu.pl.ORCID http://orcid.org/0000-0002-7119-0273
Anna DanielewiczDepartment of Human Nutrition, University of Warmia and Mazury, ul. Sloneczna 45f, 10-718, Olsztyn, Poland.ORCID http://orcid.org/0000-0002-3684-4278
Katarzyna PrzybyłowiczDepartment of Human Nutrition, University of Warmia and Mazury, ul. Sloneczna 45f, 10-718, Olsztyn, Poland.ORCID http://orcid.org/0000-0003-1061-8448
Hongmei ZengNational Cancer Registry Office, National Cancer Center, 17 South Lane, Beijing, 100021, China.
Georg HoffmannDepartment of Nutritional Sciences, University of Vienna, Althanstraße 14, UZA II, 1090, Vienna, Austria.
Lukas SchwingshacklInstitute for Evidence in Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 153, 79110, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3407-7594
University of Warmia and Mazury in Olsztyn · PLHarvard University · USUniversity of Freiburg · DEUniversity of Vienna · AT

Funding

Ministerstwo Nauki i Szkolnictwa Wyższego 010/RID/2018/19
6 · The paper itself

Abstract

purposeThe aim of current systematic review was to update the body of evidence on associations between adherence to the Mediterranean diet (MedDiet) and risk of cancer mortality, site-specific cancer in the general population; all-cause, and cancer mortality as well as cancer reoccurrence among cancer survivors.

methodsA literature search for randomized controlled trials (RCTs), case-control and cohort studies published up to April 2020 was performed using PubMed and Scopus. Study-specific risk estimates for the highest versus lowest adherence to the MedDiet category were pooled using random-effects meta-analyses. Certainty of evidence from cohort studies and RCTs was evaluated using the NutriGrade scoring system.

resultsThe updated search revealed 44 studies not identified in the previous review. Altogether, 117 studies including 3,202,496 participants were enclosed for meta-analysis. The highest adherence to MedDiet was inversely associated with cancer mortality (RR

conclusionIn conclusion, our results suggest that highest adherence to the MedDiet was related to lower risk of cancer mortality in the general population, and all-cause mortality among cancer survivors as well as colorectal, head and neck, respiratory, gastric, liver and bladder cancer risks. Moderate certainty of evidence from cohort studies suggest an inverse association for cancer mortality and colorectal cancer, but most of the comparisons were rated as low or very low certainty of evidence.

Indexed as

Diet, MediterraneanNeoplasmsCase-Control StudiesCohort StudiesHumansMaleRiskCancerCertainty of evidenceMediterranean dietMeta-analysis

Identifiers

PMID32770356
PMCPMC7987633
OpenAlexW3047947891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.