Evidence map›Paper›PMID 32770342›Full record

ArticleNeurocritical care2021

Cerebral Microembolism in Intracerebral Hemorrhage: A Prospective Case-Control Study.

Eva A Rocha, Felipe Rocha, Izadora Deliberalli, João Brainer C de Andrade, Irapuá F Ricarte, Aneesh B Singhal, Gisele S Silva

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Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Left ventricular assist device-related infections and the risk of cerebrovascular accidents: a EUROMACS study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Eva A RochaDepartment of Neurology, Universidade Federal de São Paulo, 350 Pedro de Toledo Street, São Paulo, SP, 04039-002, Brazil. eva.rochac@gmail.com.ORCID http://orcid.org/0000-0002-0981-3919
Felipe RochaDepartment of Neurology, Universidade Federal de São Paulo, 350 Pedro de Toledo Street, São Paulo, SP, 04039-002, Brazil.
Izadora DeliberalliDepartment of Neurology, Universidade Federal de São Paulo, 350 Pedro de Toledo Street, São Paulo, SP, 04039-002, Brazil.
João Brainer C de AndradeDepartment of Neurology, Universidade Federal de São Paulo, 350 Pedro de Toledo Street, São Paulo, SP, 04039-002, Brazil.
Irapuá F RicarteDepartment of Neurology, Universidade Federal de São Paulo, 350 Pedro de Toledo Street, São Paulo, SP, 04039-002, Brazil.
Aneesh B SinghalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gisele S SilvaDepartment of Neurology, Universidade Federal de São Paulo, 350 Pedro de Toledo Street, São Paulo, SP, 04039-002, Brazil.
Universidade Federal de São Paulo · BRHarvard University · USHospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall and remote acute ischemic lesions may occur in up to one-third of patients with spontaneous intracerebral hemorrhage (ICH). Possible mechanisms include cerebral embolism, small vessel disease, blood pressure variability and others. The embolic mechanism has not been adequately studied. Using transcranial Doppler (TCD), we assessed the incidence of spontaneous microembolic signals (MESs) in patients with acute ICH.

methodsTwenty acute ICH patients were prospectively evaluated within 48 h of hospital admission. Clinical and imaging data were collected. Continuous TCD monitoring was performed in both middle cerebral arteries for a one-hour period on days 1, 3 and 7 of hospital admission. Monitoring was performed in the emergency room, ICU or ward, according to patient location. We compared the frequency and risk factors for MES in patients with ICH and in 20 age- and gender-matched controls without history of ischemic or hemorrhagic stroke.

resultsThe mean age was 57.5 ± 14.1 years, and 60% were male. MESs were detected in 7 patients with ICH and in one control patient without ICH (35% vs 5%, p = 0.048). The frequency of MES on day 1 was 15% (3 of 20 patients), on day 3, 26% (5 of 19 patients) and on day 7, 37.5% (3 of 8 patients). Among patients with ICH, those with MES had a tendency to higher frequencies of dyslipidemia (83% vs 33%, p = 0.13) and lobar location of hemorrhages (71% vs 30%, p = 0.15). Two out of 6 patients with ICH who also underwent MRI had remote DWI lesions, of whom one showed MES on TCD.

conclusionMicro-embolic signals occur in over one-third of patients with ICH. Further research is needed to identify the sources of cerebral microembolism and their relationship with small acute infarcts in ICH.

Indexed as

Cerebral HemorrhageIntracranial EmbolismCase-Control StudiesHumansMaleMiddle AgedMiddle Cerebral ArteryUltrasonography, Doppler, TranscranialCerebral embolismDiffusion-weighted magnetic resonance imagingIntracranial hemorrhageTranscranial Doppler

Identifiers

PMID32770342
OpenAlexW3047844486

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.